HLA antigens in Italian multiple sclerosis patients

L. La Mantia, M. T. Illeni, C. Milanese, A. Salmaggi, M. Eoli, G. Pellegris, A. Nespolo

Research output: Contribution to journalArticlepeer-review


We analyzed HLA-A,-C,-B,-DR and-DQ specificities in 104 Italian multiple sclerosis patients and in 905 healthy controls. The frequencies of HLA-A23, A26, Cw4, DR3 and, especially DR5 antigens were significantly higher in multiple sclerosis patients than in controls. Patients with progressive course were characterized by high frequencies of B7, B8 and DR3 antigens: Cw1 and DRw11 show a negative correlation with the extent of intrathecal IgG production. These data confirm that the HLA system may influence the clinical expression and the immune responses to the disease.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalItalian Journal of Neurological Sciences
Issue number1
Publication statusPublished - Feb 1991


  • cerebrospinal fluid
  • HLA
  • Multiple sclerosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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