HLA antigens in juvenile dermatitis herpetiformis

P. Richiardi, I. Borelli, F. Malavasi, E. S. Curtoni, E. Berti, F. Gianotti, A. Giannetti

Research output: Contribution to journalArticle

Abstract

The incidence of histocompatibility antigens HLA-A, B, C, DR was studied in 32 Italian children with dermatitis herpetiformis. A significantly increased relative risk was found for B8 (R.R. = 6.2), which was present in 50% of the patients as against 14% of the controls and for DR3 (R.R. = 11.7), present in 69% of the patients as against 16%. DR7 also appeared to be increased, but only among DR3-negative patients. There was no significant difference in the incidence of DR3 between children with abnormal and normal jejunal biopsy, though there does seem to be a difference in expressivity of the intestinal involvement between DR3 apparent homozygous, DR3 heterozygous and DR3-negative patients.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalActa Dermato-Venereologica
Volume61
Issue number3
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Dermatology

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    Richiardi, P., Borelli, I., Malavasi, F., Curtoni, E. S., Berti, E., Gianotti, F., & Giannetti, A. (1981). HLA antigens in juvenile dermatitis herpetiformis. Acta Dermato-Venereologica, 61(3), 241-244.