HLA-associated susceptibility to HIV-1 infection

G. Fabio, R. Scorza, A. Lazzarin, M. Marchini, M. Zarantonello, A. D'Arminio, P. Marchisio, A. Plebani, R. Luzzati, P. Costigliola

Research output: Contribution to journalArticlepeer-review

Abstract

We studied HLA antigen distribution of 50 heterosexual partners of HIV+ drug abusers with more than 1 year of sexual exposure to HIV, 36 children born to seopositive mothers and 61 haemophiliac patients exposed to presumably infectious clotting factor concentrates. B52 and B44 antigens were associated with HIV resistance while B51 was associated with HIV susceptibility. Forty-nine HIV+ drug abusers, spouses of heterosexual partners studied and 25 HIV+ mothers of the children were also typed. DR11 phenotype was associated with infectiousness of HIV+ subjects. Our data suggest that the HLA region controls suceptibility to infection with HIV and infectiousness of HIV+ subjects in different risk groups.

Original languageEnglish
Pages (from-to)20-23
Number of pages4
JournalClinical and Experimental Immunology
Volume87
Issue number1
Publication statusPublished - 1992

Keywords

  • HIV-1
  • HLA
  • Susceptibility to infection

ASJC Scopus subject areas

  • Immunology

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