HLA-B* 5808, a new HLA-B allele characterized by sequence based typing

F. Poli, L. Crespiatico, S. Frison, E. Longhi, E. Marlianici, M. Scalamogna

Research output: Contribution to journalArticlepeer-review

Abstract

This brief communication describes a new HLA-B allele (HLA-B*5808) detected in an Italian white volunteer bone marrow donor. With serology, this subject was typed as HLA-B15,17, whereas with molecular biology B*15, B*51, B*52 and/or B*58 could be assigned. In order to clarify the results, direct and cloning sequencing of exons 2, 3 and 4 were carried out. This new allele is identical to HLA-B*5801 in exon 2 except for a silent point mutation at nucleotide 141 where a C is substituted by a T; exons 3 and 4 are typical of HLA-B*51, B*52 and B*78. The peculiar sequence of B*5808 could explain the discrepancy between the serological and molecular typing results.

Original languageEnglish
Pages (from-to)551-553
Number of pages3
JournalTissue Antigens
Volume62
Issue number6
DOIs
Publication statusPublished - Dec 2003

Keywords

  • HLA
  • SBT

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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