HLA-B13 and chronic calcific pancreatitis

L. Gullo, P. L. Tabacchi, G. R. Corazza, F. Calanca, O. Campione, G. Labò

Research output: Contribution to journalArticlepeer-review


In view of a possible role of genetic factors in the etiology of chronic calcific pancreatitis, we undertook a study of the frequency of HLA antigens in this disease. Sixty-four patients with chronic calcific pancreatitis were typed for the HLA-A,-B and-C loci. Fourteen of these 64 patients (21.9%) were found to have antigen B13 compared to 7.5% of 425 controls. These results have a P value of 0.00059 which remains significant (P=0.020) even when multiplied by the total number of antigens tested. Sex, alcoholism, age at the clinical onset of the disease, presence of pain, and diabetes had no apparent influence on the distribution of HLA alleles. The significant association between chronic calcific pancreatitis and HLA antigen B13 further supports the role of genetic factors in the etiology of the disease.

Original languageEnglish
Pages (from-to)214-216
Number of pages3
JournalDigestive Diseases and Sciences
Issue number3
Publication statusPublished - Mar 1982

ASJC Scopus subject areas

  • Gastroenterology


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