In this brief communication, we describe a novel human leukocyte antigen-B (HLA-B) allele (HLA-B*1819). This allele, found in an Italian Caucasian individual, differs from HLA-B*180101 by three nucleotide changes in exon 3. These mutations are located at positions 527, 538, and 539 where a T, a C, and a T are substituted respectively, by an A, a T, and a G, leading to three aminoacidic substitutions at codon 152 from Valine to Glutamic Acid (GTG→GAG), at codon 155 from Histidine to Glutamine (CAC→CAG), and at codon 156 from Cysteine to Tryptophan (TGT→TGG).
ASJC Scopus subject areas
- Cell Biology