HLA class I, II, and III polymorphism in Italian patients with sarcoidosis

L. Pasturenzi, M. Martinetti, M. Cuccia, A. Cipriani, G. Semenzato, M. Luisetti, A. Bulgheroni, A. M. Donnetta, V. Peona, C. Daielli, O. Finco, G. Semenzato, A. Tommasini

Research output: Contribution to journalArticlepeer-review

Abstract

We studied the HLA polymorphisms (class I, II, and III) in 107 Italian patients with biopsy specimen-proven sarcoidosis in order to investigate the immunogenetic background of this disease. The mean age of onset of the disease was 36.08 ± 12.4 years. Four patients (3.73 percent) were in radiologic stage 0, 38 patients (35.51 percent) were in radiologic stage I, 40 patients (37.38 percent) were in stage II, and 25 (23.36 percent) were in stage III. Thirty-eight patients (35.51 percent) had one or more extrapulmonary localization(s) of the disease. Positive association between sarcoidosis and HLA-B8 (χ2=6.07, p=0.0127, RR=1.91) was confirmed. Regarding the age of onset of the disease, HLA-B35 was more frequent (χ2=7.34, p=0.0056, pc 2=7.22, p=0.0061, pc

Original languageEnglish
Pages (from-to)1170-1175
Number of pages6
JournalChest
Volume104
Issue number4
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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