HLA class-I-soluble antigen serum levels in liver transplantation. A predictor marker of acute rejection

Francesco Puppo, Riccardo Pellicci, Sabrina Brenci, Arcangelo Nocera, Nicola Morelli, Giovanni Dardano, Massimo Bertocchi, Adelmo Antonucci, Massimo Ghio, Marco Scudeletti, Sergio Barocci, Umberto Valente, Francesco Indiveri

Research output: Contribution to journalArticle

Abstract

The serum levels of sHLA-I have been determined in 16 patients following liver transplantation. sHLA-I levels did not show remarkable variations in six patients without evidence of transplant-related complications. sHLA-I levels strongly increased in 10 patients undergoing acute rejection episodes. In these patients, an average 20% daily increase of sHLA-I levels was detected on the 6 days preceding and on the 2 days following the rejection episode. A fast decrease of sHLA-I levels was observed in seven patients following treatment of acute rejection with anti-CD3 mAb. The serum level of sHLA-I antigens positively correlated with ALT serum level and inversely correlated with PT. The determination of sHLA-I in serum may therefore be proposed as a useful marker in the monitoring of patients following liver transplantation. The increase of sHLA-I antigens may predict the onset of acute rejection whereas their decrease may be related to a good response of acute rejection to immunosuppressive treatment.

Original languageEnglish
Pages (from-to)166-170
Number of pages5
JournalHuman Immunology
Volume40
Issue number3
DOIs
Publication statusPublished - 1994

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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    Puppo, F., Pellicci, R., Brenci, S., Nocera, A., Morelli, N., Dardano, G., Bertocchi, M., Antonucci, A., Ghio, M., Scudeletti, M., Barocci, S., Valente, U., & Indiveri, F. (1994). HLA class-I-soluble antigen serum levels in liver transplantation. A predictor marker of acute rejection. Human Immunology, 40(3), 166-170. https://doi.org/10.1016/0198-8859(94)90063-9