HLA class I specific inhibitory receptors

Alessandro Moretta, Lorenzo Moretta

Research output: Contribution to journalArticlepeer-review


All human natural killer cells and some memory T cells express HLA class I receptors, so-called natural killer cell receptors (NKRs), a receptor class that in the past few years has been shown to include several members of the immunoglobulin superfamily and the C-type lectin CD94-NKG2A complex. NKR ligand mediated cross-linking leads to the recruitment and activation of a tyrosine phosphatase involved in downregulating the phosphorylation of effector molecules involved in cell triggering. Thus, NKR engagement leads to the inhibition of different NK and T cell functions.

Original languageEnglish
Pages (from-to)694-701
Number of pages8
JournalCurrent Opinion in Immunology
Issue number5
Publication statusPublished - Oct 1997

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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