TY - JOUR
T1 - HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations
AU - Spurkland, A.
AU - Saarinen, S.
AU - Boberg, K. M.
AU - Mitchell, S.
AU - Broome, U.
AU - Caballeria, L.
AU - Ciusani, E.
AU - Chapman, R.
AU - Ercilla, G.
AU - Fausa, O.
AU - Knutsen, I.
AU - Pares, A.
AU - Rosina, F.
AU - Olerup, O.
AU - Thorsby, E.
AU - Schrump, E.
PY - 1999
Y1 - 1999
N2 - The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR = 3.0, P <0.00001) and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes (RR = 2.4, P <0.0001) were observed in all five patient groups. A total of 16% of the PSC patients were homozygous for the DRB1*03, DQA1*0501, DQB1*02 haplotype compared to 1% of the controls (RR = 20, P <0.0001). The DRB1*04, DQA1*03, DQB1*0302 haplotype was significantly reduced in frequency (RR = 0.4, P <0.00001). Among Norwegian, Swedish and British patients that did not carry neither the DRB1*03, DQA1*0501, DQB1*02 nor the DRB1*13, DQA1*0103, DQB1*0603 haplotype, an increased frequency of the DRB1*15, DQA1*0102, DQB1*0602 haplo type was observed (RR = 2.0, P <0.0001). Thus, PSC was found to be positively associated to three different HLA class II haplotypes (i.e. the DRB1*03, DQA1*0501, DQB1*02, the DRB1*15, DQA1*0102, DQB1*0602 and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes) and negatively associated to one HLA class II haplotype (i.e. the DRB1*04, DQB1*0302 haplotype).
AB - The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR = 3.0, P <0.00001) and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes (RR = 2.4, P <0.0001) were observed in all five patient groups. A total of 16% of the PSC patients were homozygous for the DRB1*03, DQA1*0501, DQB1*02 haplotype compared to 1% of the controls (RR = 20, P <0.0001). The DRB1*04, DQA1*03, DQB1*0302 haplotype was significantly reduced in frequency (RR = 0.4, P <0.00001). Among Norwegian, Swedish and British patients that did not carry neither the DRB1*03, DQA1*0501, DQB1*02 nor the DRB1*13, DQA1*0103, DQB1*0603 haplotype, an increased frequency of the DRB1*15, DQA1*0102, DQB1*0602 haplo type was observed (RR = 2.0, P <0.0001). Thus, PSC was found to be positively associated to three different HLA class II haplotypes (i.e. the DRB1*03, DQA1*0501, DQB1*02, the DRB1*15, DQA1*0102, DQB1*0602 and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes) and negatively associated to one HLA class II haplotype (i.e. the DRB1*04, DQB1*0302 haplotype).
KW - Disease susceptibility genes
KW - HL4 class II genes
KW - Primary sclerosing cholangitis
UR - http://www.scopus.com/inward/record.url?scp=0032907060&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032907060&partnerID=8YFLogxK
U2 - 10.1034/j.1399-0039.1999.530502.x
DO - 10.1034/j.1399-0039.1999.530502.x
M3 - Article
C2 - 10372541
AN - SCOPUS:0032907060
VL - 53
SP - 459
EP - 469
JO - Tissue Antigens
JF - Tissue Antigens
SN - 0001-2815
IS - 5
ER -