HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations

A. Spurkland; S. Saarinen; K. M. Boberg; S. Mitchell; U. Broome; L. Caballeria; E. Ciusani; R. Chapman; G. Ercilla; O. Fausa; I. Knutsen; A. Pares; F. Rosina; O. Olerup; E. Thorsby; E. Schrump

doi:10.1034/j.1399-0039.1999.530502.x

HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations

A. Spurkland, S. Saarinen, K. M. Boberg, S. Mitchell, U. Broome, L. Caballeria, E. Ciusani, R. Chapman, G. Ercilla, O. Fausa, I. Knutsen, A. Pares, F. Rosina, O. Olerup, E. Thorsby, E. Schrump

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR = 3.0, P <0.00001) and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes (RR = 2.4, P <0.0001) were observed in all five patient groups. A total of 16% of the PSC patients were homozygous for the DRB1*03, DQA1*0501, DQB1*02 haplotype compared to 1% of the controls (RR = 20, P <0.0001). The DRB1*04, DQA1*03, DQB1*0302 haplotype was significantly reduced in frequency (RR = 0.4, P <0.00001). Among Norwegian, Swedish and British patients that did not carry neither the DRB1*03, DQA1*0501, DQB1*02 nor the DRB1*13, DQA1*0103, DQB1*0603 haplotype, an increased frequency of the DRB1*15, DQA1*0102, DQB1*0602 haplo type was observed (RR = 2.0, P <0.0001). Thus, PSC was found to be positively associated to three different HLA class II haplotypes (i.e. the DRB1*03, DQA1*0501, DQB1*02, the DRB1*15, DQA1*0102, DQB1*0602 and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes) and negatively associated to one HLA class II haplotype (i.e. the DRB1*04, DQB1*0302 haplotype).

Original language	English
Pages (from-to)	459-469
Number of pages	11
Journal	Tissue Antigens
Volume	53
Issue number	5
DOIs	https://doi.org/10.1034/j.1399-0039.1999.530502.x
Publication status	Published - 1999

Keywords

Disease susceptibility genes
HL4 class II genes
Primary sclerosing cholangitis

ASJC Scopus subject areas

Immunology
Cell Biology

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10.1034/j.1399-0039.1999.530502.x

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Spurkland, A., Saarinen, S., Boberg, K. M., Mitchell, S., Broome, U., Caballeria, L., Ciusani, E., Chapman, R., Ercilla, G., Fausa, O., Knutsen, I., Pares, A., Rosina, F., Olerup, O., Thorsby, E., & Schrump, E. (1999). HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations. Tissue Antigens, 53(5), 459-469. https://doi.org/10.1034/j.1399-0039.1999.530502.x

HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations. / Spurkland, A.; Saarinen, S.; Boberg, K. M.; Mitchell, S.; Broome, U.; Caballeria, L.; Ciusani, E.; Chapman, R.; Ercilla, G.; Fausa, O.; Knutsen, I.; Pares, A.; Rosina, F.; Olerup, O.; Thorsby, E.; Schrump, E.

In: Tissue Antigens, Vol. 53, No. 5, 1999, p. 459-469.

Research output: Contribution to journal › Article › peer-review

Spurkland, A, Saarinen, S, Boberg, KM, Mitchell, S, Broome, U, Caballeria, L, Ciusani, E, Chapman, R, Ercilla, G, Fausa, O, Knutsen, I, Pares, A, Rosina, F, Olerup, O, Thorsby, E & Schrump, E 1999, 'HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations', Tissue Antigens, vol. 53, no. 5, pp. 459-469. https://doi.org/10.1034/j.1399-0039.1999.530502.x

Spurkland, A. ; Saarinen, S. ; Boberg, K. M. ; Mitchell, S. ; Broome, U. ; Caballeria, L. ; Ciusani, E. ; Chapman, R. ; Ercilla, G. ; Fausa, O. ; Knutsen, I. ; Pares, A. ; Rosina, F. ; Olerup, O. ; Thorsby, E. ; Schrump, E. / HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations. In: Tissue Antigens. 1999 ; Vol. 53, No. 5. pp. 459-469.

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title = "HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations",

abstract = "The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR = 3.0, P <0.00001) and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes (RR = 2.4, P <0.0001) were observed in all five patient groups. A total of 16% of the PSC patients were homozygous for the DRB1*03, DQA1*0501, DQB1*02 haplotype compared to 1% of the controls (RR = 20, P <0.0001). The DRB1*04, DQA1*03, DQB1*0302 haplotype was significantly reduced in frequency (RR = 0.4, P <0.00001). Among Norwegian, Swedish and British patients that did not carry neither the DRB1*03, DQA1*0501, DQB1*02 nor the DRB1*13, DQA1*0103, DQB1*0603 haplotype, an increased frequency of the DRB1*15, DQA1*0102, DQB1*0602 haplo type was observed (RR = 2.0, P <0.0001). Thus, PSC was found to be positively associated to three different HLA class II haplotypes (i.e. the DRB1*03, DQA1*0501, DQB1*02, the DRB1*15, DQA1*0102, DQB1*0602 and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes) and negatively associated to one HLA class II haplotype (i.e. the DRB1*04, DQB1*0302 haplotype).",

keywords = "Disease susceptibility genes, HL4 class II genes, Primary sclerosing cholangitis",

author = "A. Spurkland and S. Saarinen and Boberg, {K. M.} and S. Mitchell and U. Broome and L. Caballeria and E. Ciusani and R. Chapman and G. Ercilla and O. Fausa and I. Knutsen and A. Pares and F. Rosina and O. Olerup and E. Thorsby and E. Schrump",

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T1 - HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations

AU - Spurkland, A.

AU - Saarinen, S.

AU - Boberg, K. M.

AU - Mitchell, S.

AU - Broome, U.

AU - Caballeria, L.

AU - Ciusani, E.

AU - Chapman, R.

AU - Ercilla, G.

AU - Fausa, O.

AU - Knutsen, I.

AU - Pares, A.

AU - Rosina, F.

AU - Olerup, O.

AU - Thorsby, E.

AU - Schrump, E.

PY - 1999

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N2 - The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR = 3.0, P <0.00001) and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes (RR = 2.4, P <0.0001) were observed in all five patient groups. A total of 16% of the PSC patients were homozygous for the DRB1*03, DQA1*0501, DQB1*02 haplotype compared to 1% of the controls (RR = 20, P <0.0001). The DRB1*04, DQA1*03, DQB1*0302 haplotype was significantly reduced in frequency (RR = 0.4, P <0.00001). Among Norwegian, Swedish and British patients that did not carry neither the DRB1*03, DQA1*0501, DQB1*02 nor the DRB1*13, DQA1*0103, DQB1*0603 haplotype, an increased frequency of the DRB1*15, DQA1*0102, DQB1*0602 haplo type was observed (RR = 2.0, P <0.0001). Thus, PSC was found to be positively associated to three different HLA class II haplotypes (i.e. the DRB1*03, DQA1*0501, DQB1*02, the DRB1*15, DQA1*0102, DQB1*0602 and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes) and negatively associated to one HLA class II haplotype (i.e. the DRB1*04, DQB1*0302 haplotype).

AB - The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR = 3.0, P <0.00001) and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes (RR = 2.4, P <0.0001) were observed in all five patient groups. A total of 16% of the PSC patients were homozygous for the DRB1*03, DQA1*0501, DQB1*02 haplotype compared to 1% of the controls (RR = 20, P <0.0001). The DRB1*04, DQA1*03, DQB1*0302 haplotype was significantly reduced in frequency (RR = 0.4, P <0.00001). Among Norwegian, Swedish and British patients that did not carry neither the DRB1*03, DQA1*0501, DQB1*02 nor the DRB1*13, DQA1*0103, DQB1*0603 haplotype, an increased frequency of the DRB1*15, DQA1*0102, DQB1*0602 haplo type was observed (RR = 2.0, P <0.0001). Thus, PSC was found to be positively associated to three different HLA class II haplotypes (i.e. the DRB1*03, DQA1*0501, DQB1*02, the DRB1*15, DQA1*0102, DQB1*0602 and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes) and negatively associated to one HLA class II haplotype (i.e. the DRB1*04, DQB1*0302 haplotype).

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HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations

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Keywords

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