HLA class II haplotypes in primary sclerosing cholangitis patients from five European populations

A. Spurkland, S. Saarinen, K. M. Boberg, S. Mitchell, U. Broome, L. Caballeria, E. Ciusani, R. Chapman, G. Ercilla, O. Fausa, I. Knutsen, A. Pares, F. Rosina, O. Olerup, E. Thorsby, E. Schrump

Research output: Contribution to journalArticlepeer-review

Abstract

The association of primary sclerosing cholangitis (PSC) to HLA class II genes was studied by comparing patients from five different European populations. Deduced HLA-DRB1, DQA1, DQB1 haplotypes of 256 PSC patients from England, Italy, Norway, Spain and Sweden were compared to those observed in 764 ethnically-matched controls. Increased frequencies of the DRB1*03, DQA1*0501, DQB1*02 (RR = 3.0, P <0.00001) and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes (RR = 2.4, P <0.0001) were observed in all five patient groups. A total of 16% of the PSC patients were homozygous for the DRB1*03, DQA1*0501, DQB1*02 haplotype compared to 1% of the controls (RR = 20, P <0.0001). The DRB1*04, DQA1*03, DQB1*0302 haplotype was significantly reduced in frequency (RR = 0.4, P <0.00001). Among Norwegian, Swedish and British patients that did not carry neither the DRB1*03, DQA1*0501, DQB1*02 nor the DRB1*13, DQA1*0103, DQB1*0603 haplotype, an increased frequency of the DRB1*15, DQA1*0102, DQB1*0602 haplo type was observed (RR = 2.0, P <0.0001). Thus, PSC was found to be positively associated to three different HLA class II haplotypes (i.e. the DRB1*03, DQA1*0501, DQB1*02, the DRB1*15, DQA1*0102, DQB1*0602 and the DRB1*13, DQA1*0103, DQB1*0603 haplotypes) and negatively associated to one HLA class II haplotype (i.e. the DRB1*04, DQB1*0302 haplotype).

Original languageEnglish
Pages (from-to)459-469
Number of pages11
JournalTissue Antigens
Volume53
Issue number5
DOIs
Publication statusPublished - 1999

Keywords

  • Disease susceptibility genes
  • HL4 class II genes
  • Primary sclerosing cholangitis

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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