HLA complement markers in Italian narcoleptic patients with special emphasis on BfF subtyping

M. Cuccia, O. Finco, R. Conte, F. Cirignotta, G. Ruberto

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Thirty narcoleptic patients (29 out of 30 of Mediterranean origin) were studied for HLA polymorphisms (only 24 were investigated for HLA class III). We found that these patients are characterized by DR2, DQW2 phenotype (p <0.0001) as those of Anglo-Saxon origin so far studied and by the complotype: BfS, C4A3, C4B1. Just 1 of 7 BfF patients has the Fb subtype detected by isoelectric focusing technique (p = 0.007). The only patient of Black origin (his mother is Eritrean) is completely different for mother patients (DR3,5; DQW2,W3; C4A4,4; C4B 1,2), supporting the hypothesis that it is not the DR2, DQW1 phenotype per se involved in this syndrome. Subdividing the subjects according to different clinical features, we cannot demonstrate genetic heterogeneity.

Original languageEnglish
Pages (from-to)86-91
Number of pages6
JournalComplement and Inflammation
Issue number2
Publication statusPublished - 1991



  • BfF subtyping
  • C4 and Bf complement factors
  • HLA histoglobulins
  • narcolepsy

ASJC Scopus subject areas

  • Immunology
  • Hematology

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