HLA-DP polymorphism in northern Italian celiac patients

V. Mantovani, G. R. Corazza, M. Frisoni, M. G. Zaniboni, M. Bragliani, R. A. Valentini, P. Barboni, A. Lambertini, G. Gasbarrini

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Abstract

The contribution of HLA-DP genes to celiac disease susceptibility has been investigated in 95 Italian patients, 41 with childhood and 54 with adult disease onset. Polymerase chain reaction amplification, sequence-specific oligonucleotide probe hybridization and restriction fragment length polymorphism analyses have been carried out. All celiac patients and 56 out of 128 random healthy controls were DQw2-positive. The frequency of the DPB1*0101 allele was significantly increased (p(c)= 0.002, relative risk 5.21) in patients with celiac disease (23.2%) compared to the whole panel of controls (5.5%), but not to the 56 controls bearing DQw2 (10.7%). No significant difference in the frequency of DPB1*0101 was found between celiac patients with pediatric (24.4%,) or adult (22.2%) onset. The DPB1*0101 allele was associated with both the DR3-DQw2 and DR7-DQw2 haplotypes. Moreover, our study has not confirmed the association with DPB1*0402 and DPB1*0301 previously reported in celiac children from southern Italy. The linkage of the DPB1*0101 allele with the DQ locus and the observation that the DP but not the DQ association appears to be ethnically dependent strongly support a secondary role of DP molecules in celiac disease susceptibility.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalTissue Antigens
Volume40
Issue number4
Publication statusPublished - 1992

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Keywords

  • Celiac disease
  • HLA-DP

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Mantovani, V., Corazza, G. R., Frisoni, M., Zaniboni, M. G., Bragliani, M., Valentini, R. A., Barboni, P., Lambertini, A., & Gasbarrini, G. (1992). HLA-DP polymorphism in northern Italian celiac patients. Tissue Antigens, 40(4), 182-186.