HLA-DP polymorphism in northern Italian celiac patients

V. Mantovani, G. R. Corazza, M. Frisoni, M. G. Zaniboni, M. Bragliani, R. A. Valentini, P. Barboni, A. Lambertini, G. Gasbarrini

Research output: Contribution to journalArticle

Abstract

The contribution of HLA-DP genes to celiac disease susceptibility has been investigated in 95 Italian patients, 41 with childhood and 54 with adult disease onset. Polymerase chain reaction amplification, sequence-specific oligonucleotide probe hybridization and restriction fragment length polymorphism analyses have been carried out. All celiac patients and 56 out of 128 random healthy controls were DQw2-positive. The frequency of the DPB1*0101 allele was significantly increased (p(c)= 0.002, relative risk 5.21) in patients with celiac disease (23.2%) compared to the whole panel of controls (5.5%), but not to the 56 controls bearing DQw2 (10.7%). No significant difference in the frequency of DPB1*0101 was found between celiac patients with pediatric (24.4%,) or adult (22.2%) onset. The DPB1*0101 allele was associated with both the DR3-DQw2 and DR7-DQw2 haplotypes. Moreover, our study has not confirmed the association with DPB1*0402 and DPB1*0301 previously reported in celiac children from southern Italy. The linkage of the DPB1*0101 allele with the DQ locus and the observation that the DP but not the DQ association appears to be ethnically dependent strongly support a secondary role of DP molecules in celiac disease susceptibility.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalTissue Antigens
Volume40
Issue number4
Publication statusPublished - 1992

Fingerprint

HLA-DP Antigens
Polymorphism
Abdomen
Celiac Disease
Alleles
Disease Susceptibility
Bearings (structural)
Pediatrics
Oligonucleotide Probes
Polymerase chain reaction
Restriction Fragment Length Polymorphisms
Haplotypes
Italy
Amplification
Genes
Polymerase Chain Reaction
Molecules

Keywords

  • Celiac disease
  • HLA-DP

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Mantovani, V., Corazza, G. R., Frisoni, M., Zaniboni, M. G., Bragliani, M., Valentini, R. A., ... Gasbarrini, G. (1992). HLA-DP polymorphism in northern Italian celiac patients. Tissue Antigens, 40(4), 182-186.

HLA-DP polymorphism in northern Italian celiac patients. / Mantovani, V.; Corazza, G. R.; Frisoni, M.; Zaniboni, M. G.; Bragliani, M.; Valentini, R. A.; Barboni, P.; Lambertini, A.; Gasbarrini, G.

In: Tissue Antigens, Vol. 40, No. 4, 1992, p. 182-186.

Research output: Contribution to journalArticle

Mantovani, V, Corazza, GR, Frisoni, M, Zaniboni, MG, Bragliani, M, Valentini, RA, Barboni, P, Lambertini, A & Gasbarrini, G 1992, 'HLA-DP polymorphism in northern Italian celiac patients', Tissue Antigens, vol. 40, no. 4, pp. 182-186.
Mantovani V, Corazza GR, Frisoni M, Zaniboni MG, Bragliani M, Valentini RA et al. HLA-DP polymorphism in northern Italian celiac patients. Tissue Antigens. 1992;40(4):182-186.
Mantovani, V. ; Corazza, G. R. ; Frisoni, M. ; Zaniboni, M. G. ; Bragliani, M. ; Valentini, R. A. ; Barboni, P. ; Lambertini, A. ; Gasbarrini, G. / HLA-DP polymorphism in northern Italian celiac patients. In: Tissue Antigens. 1992 ; Vol. 40, No. 4. pp. 182-186.
@article{973f6d3daeb448f0b2f08017eddc1e22,
title = "HLA-DP polymorphism in northern Italian celiac patients",
abstract = "The contribution of HLA-DP genes to celiac disease susceptibility has been investigated in 95 Italian patients, 41 with childhood and 54 with adult disease onset. Polymerase chain reaction amplification, sequence-specific oligonucleotide probe hybridization and restriction fragment length polymorphism analyses have been carried out. All celiac patients and 56 out of 128 random healthy controls were DQw2-positive. The frequency of the DPB1*0101 allele was significantly increased (p(c)= 0.002, relative risk 5.21) in patients with celiac disease (23.2{\%}) compared to the whole panel of controls (5.5{\%}), but not to the 56 controls bearing DQw2 (10.7{\%}). No significant difference in the frequency of DPB1*0101 was found between celiac patients with pediatric (24.4{\%},) or adult (22.2{\%}) onset. The DPB1*0101 allele was associated with both the DR3-DQw2 and DR7-DQw2 haplotypes. Moreover, our study has not confirmed the association with DPB1*0402 and DPB1*0301 previously reported in celiac children from southern Italy. The linkage of the DPB1*0101 allele with the DQ locus and the observation that the DP but not the DQ association appears to be ethnically dependent strongly support a secondary role of DP molecules in celiac disease susceptibility.",
keywords = "Celiac disease, HLA-DP",
author = "V. Mantovani and Corazza, {G. R.} and M. Frisoni and Zaniboni, {M. G.} and M. Bragliani and Valentini, {R. A.} and P. Barboni and A. Lambertini and G. Gasbarrini",
year = "1992",
language = "English",
volume = "40",
pages = "182--186",
journal = "Tissue Antigens",
issn = "0001-2815",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - HLA-DP polymorphism in northern Italian celiac patients

AU - Mantovani, V.

AU - Corazza, G. R.

AU - Frisoni, M.

AU - Zaniboni, M. G.

AU - Bragliani, M.

AU - Valentini, R. A.

AU - Barboni, P.

AU - Lambertini, A.

AU - Gasbarrini, G.

PY - 1992

Y1 - 1992

N2 - The contribution of HLA-DP genes to celiac disease susceptibility has been investigated in 95 Italian patients, 41 with childhood and 54 with adult disease onset. Polymerase chain reaction amplification, sequence-specific oligonucleotide probe hybridization and restriction fragment length polymorphism analyses have been carried out. All celiac patients and 56 out of 128 random healthy controls were DQw2-positive. The frequency of the DPB1*0101 allele was significantly increased (p(c)= 0.002, relative risk 5.21) in patients with celiac disease (23.2%) compared to the whole panel of controls (5.5%), but not to the 56 controls bearing DQw2 (10.7%). No significant difference in the frequency of DPB1*0101 was found between celiac patients with pediatric (24.4%,) or adult (22.2%) onset. The DPB1*0101 allele was associated with both the DR3-DQw2 and DR7-DQw2 haplotypes. Moreover, our study has not confirmed the association with DPB1*0402 and DPB1*0301 previously reported in celiac children from southern Italy. The linkage of the DPB1*0101 allele with the DQ locus and the observation that the DP but not the DQ association appears to be ethnically dependent strongly support a secondary role of DP molecules in celiac disease susceptibility.

AB - The contribution of HLA-DP genes to celiac disease susceptibility has been investigated in 95 Italian patients, 41 with childhood and 54 with adult disease onset. Polymerase chain reaction amplification, sequence-specific oligonucleotide probe hybridization and restriction fragment length polymorphism analyses have been carried out. All celiac patients and 56 out of 128 random healthy controls were DQw2-positive. The frequency of the DPB1*0101 allele was significantly increased (p(c)= 0.002, relative risk 5.21) in patients with celiac disease (23.2%) compared to the whole panel of controls (5.5%), but not to the 56 controls bearing DQw2 (10.7%). No significant difference in the frequency of DPB1*0101 was found between celiac patients with pediatric (24.4%,) or adult (22.2%) onset. The DPB1*0101 allele was associated with both the DR3-DQw2 and DR7-DQw2 haplotypes. Moreover, our study has not confirmed the association with DPB1*0402 and DPB1*0301 previously reported in celiac children from southern Italy. The linkage of the DPB1*0101 allele with the DQ locus and the observation that the DP but not the DQ association appears to be ethnically dependent strongly support a secondary role of DP molecules in celiac disease susceptibility.

KW - Celiac disease

KW - HLA-DP

UR - http://www.scopus.com/inward/record.url?scp=0026499746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026499746&partnerID=8YFLogxK

M3 - Article

C2 - 1361687

AN - SCOPUS:0026499746

VL - 40

SP - 182

EP - 186

JO - Tissue Antigens

JF - Tissue Antigens

SN - 0001-2815

IS - 4

ER -