HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus

G. D. Sebastiani, M. Galeazzi, A. Tincani, R. Scorza, A. Mathieu, G. Passiu, G. Morozzi, J. C. Piette, R. Cervera, F. Houssiau, J. Smolen, A. Fernandez Nebro, E. De Ramon, A. Jedryka Goral, C. Papasteriades, G. B. Ferrara, C. Carcassi, F. Bellisai, R. Marcolongo

Research output: Contribution to journalArticle

Abstract

Our objective was to determine the HLA-DPB1 allele associations of anticardiolipin (aCL) and anti-beta2GPI (aβ2GPI) antibodies, and of clinical manifestations of the antiphospholipid syndrome (APS), in systemic lupus erythematosus (SLE). We studied 577 European patients with SLE. aCL and aβ2GPI antibodies were measured by ELISA. Molecular typing of HLA-DPB1 locus was performed by polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) method. aCL showed positive association with -DPB1*1501 (P = 0.005, OR = 7.4), and -DPB1*2301 (P = 0.009, OR = 3.3). aβ2GPI showed positive association with -DPB1*0301 (P = 0.01, OR = 1.9), and -DPB1*1901 (P = 0.004, OR = 8.1). In addition, livedo reticularis was associated with -DPB1*1401, and Raynaud's phenomenon with -DPB1*2001. In conclusion, HLA-DPB1 locus may contribute to the genetic predisposition to develop antiphospholipid antibodies and clinical manifestations of the APS in patients with SLE.

Original languageEnglish
Pages (from-to)560-563
Number of pages4
JournalLupus
Volume12
Issue number7
DOIs
Publication statusPublished - 2003

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Keywords

  • Anti-βGPI antibodies
  • Anticardiolipin antibodies
  • Antiphospholipid syndrome
  • HLA
  • HLA-DPB1 locus
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Sebastiani, G. D., Galeazzi, M., Tincani, A., Scorza, R., Mathieu, A., Passiu, G., Morozzi, G., Piette, J. C., Cervera, R., Houssiau, F., Smolen, J., Fernandez Nebro, A., De Ramon, E., Jedryka Goral, A., Papasteriades, C., Ferrara, G. B., Carcassi, C., Bellisai, F., & Marcolongo, R. (2003). HLA-DPB1 alleles association of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. Lupus, 12(7), 560-563. https://doi.org/10.1191/0961203303lu402oa