HLA-DR antigens in HBsAg-positive chronic active liver disease with and without associated delta infection

B. Forzani, G. C. Actis, G. Verme, A. Amoroso, I. Borelli, E. S. Curtoni, M. G. Rumi, A. Picciotto, G. Marinucci, M. A. Freni

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Abstract

The A, B, C and DR locus specificities of the human leukocyte antigens system (HLA) were determined in 45 delta-positive and 44 delta-negative Italian patients, all with HBsAg-positive chronic active liver disease; controls were 526 healthy Italian blood donors matched for age, sex and geographical origin. HLA-A, B, C gene frequencies were not significantly changed. In the delta-positive patients, the frequencies of the DR locus specificities were: DR2, 37.8%; DR3, 20%; DR4, 11.1%. In the delta-negative patients, the frequencies were: DR2, 13.6%, DR3, 36.4% DR4, 0%. Control frequencies were: DR2, 19.4%; DR3, 17.1%; DR4, 18.5%. The corrected values of the differences between controls and delta-positive patients were: DR2, p(c) = 0.046; DR3, p(c) = NS (not significant); DR4, p(c) = NS. The corrected p values of the differences between controls and delta-negative patients were: DR2, p(c) = NS; DR3, p(c) = 0.03; DR4, p(c) = 0.002. These findings show that: (a) DR3, a genetic marker of autoimmunity, might assist the establishment of chronic HBsAg liver disease in the absence of delta superinfection; (b) DR2 is linked with failure to clear the delta agent, and (c) DR4 may protect from virus B persistence. Identification of adventitious factors such as delta may help uncover a subgroup of HBsAg carriers who are genetically predisposed to develop chronic liver disease.

Original languageEnglish
Pages (from-to)1107-1110
Number of pages4
JournalHepatology
Volume4
Issue number6
Publication statusPublished - 1984

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Hepatitis D
Hepatitis B Surface Antigens
HLA Antigens
Liver Diseases
Antigens
Hepatitis Delta Virus
Cercopithecine Herpesvirus 1
Blood Donors
Autoimmunity
Genetic Markers
Gene Frequency
Chronic Disease

ASJC Scopus subject areas

  • Hepatology

Cite this

Forzani, B., Actis, G. C., Verme, G., Amoroso, A., Borelli, I., Curtoni, E. S., ... Freni, M. A. (1984). HLA-DR antigens in HBsAg-positive chronic active liver disease with and without associated delta infection. Hepatology, 4(6), 1107-1110.

HLA-DR antigens in HBsAg-positive chronic active liver disease with and without associated delta infection. / Forzani, B.; Actis, G. C.; Verme, G.; Amoroso, A.; Borelli, I.; Curtoni, E. S.; Rumi, M. G.; Picciotto, A.; Marinucci, G.; Freni, M. A.

In: Hepatology, Vol. 4, No. 6, 1984, p. 1107-1110.

Research output: Contribution to journalArticle

Forzani, B, Actis, GC, Verme, G, Amoroso, A, Borelli, I, Curtoni, ES, Rumi, MG, Picciotto, A, Marinucci, G & Freni, MA 1984, 'HLA-DR antigens in HBsAg-positive chronic active liver disease with and without associated delta infection', Hepatology, vol. 4, no. 6, pp. 1107-1110.
Forzani B, Actis GC, Verme G, Amoroso A, Borelli I, Curtoni ES et al. HLA-DR antigens in HBsAg-positive chronic active liver disease with and without associated delta infection. Hepatology. 1984;4(6):1107-1110.
Forzani, B. ; Actis, G. C. ; Verme, G. ; Amoroso, A. ; Borelli, I. ; Curtoni, E. S. ; Rumi, M. G. ; Picciotto, A. ; Marinucci, G. ; Freni, M. A. / HLA-DR antigens in HBsAg-positive chronic active liver disease with and without associated delta infection. In: Hepatology. 1984 ; Vol. 4, No. 6. pp. 1107-1110.
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abstract = "The A, B, C and DR locus specificities of the human leukocyte antigens system (HLA) were determined in 45 delta-positive and 44 delta-negative Italian patients, all with HBsAg-positive chronic active liver disease; controls were 526 healthy Italian blood donors matched for age, sex and geographical origin. HLA-A, B, C gene frequencies were not significantly changed. In the delta-positive patients, the frequencies of the DR locus specificities were: DR2, 37.8{\%}; DR3, 20{\%}; DR4, 11.1{\%}. In the delta-negative patients, the frequencies were: DR2, 13.6{\%}, DR3, 36.4{\%} DR4, 0{\%}. Control frequencies were: DR2, 19.4{\%}; DR3, 17.1{\%}; DR4, 18.5{\%}. The corrected values of the differences between controls and delta-positive patients were: DR2, p(c) = 0.046; DR3, p(c) = NS (not significant); DR4, p(c) = NS. The corrected p values of the differences between controls and delta-negative patients were: DR2, p(c) = NS; DR3, p(c) = 0.03; DR4, p(c) = 0.002. These findings show that: (a) DR3, a genetic marker of autoimmunity, might assist the establishment of chronic HBsAg liver disease in the absence of delta superinfection; (b) DR2 is linked with failure to clear the delta agent, and (c) DR4 may protect from virus B persistence. Identification of adventitious factors such as delta may help uncover a subgroup of HBsAg carriers who are genetically predisposed to develop chronic liver disease.",
author = "B. Forzani and Actis, {G. C.} and G. Verme and A. Amoroso and I. Borelli and Curtoni, {E. S.} and Rumi, {M. G.} and A. Picciotto and G. Marinucci and Freni, {M. A.}",
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T1 - HLA-DR antigens in HBsAg-positive chronic active liver disease with and without associated delta infection

AU - Forzani, B.

AU - Actis, G. C.

AU - Verme, G.

AU - Amoroso, A.

AU - Borelli, I.

AU - Curtoni, E. S.

AU - Rumi, M. G.

AU - Picciotto, A.

AU - Marinucci, G.

AU - Freni, M. A.

PY - 1984

Y1 - 1984

N2 - The A, B, C and DR locus specificities of the human leukocyte antigens system (HLA) were determined in 45 delta-positive and 44 delta-negative Italian patients, all with HBsAg-positive chronic active liver disease; controls were 526 healthy Italian blood donors matched for age, sex and geographical origin. HLA-A, B, C gene frequencies were not significantly changed. In the delta-positive patients, the frequencies of the DR locus specificities were: DR2, 37.8%; DR3, 20%; DR4, 11.1%. In the delta-negative patients, the frequencies were: DR2, 13.6%, DR3, 36.4% DR4, 0%. Control frequencies were: DR2, 19.4%; DR3, 17.1%; DR4, 18.5%. The corrected values of the differences between controls and delta-positive patients were: DR2, p(c) = 0.046; DR3, p(c) = NS (not significant); DR4, p(c) = NS. The corrected p values of the differences between controls and delta-negative patients were: DR2, p(c) = NS; DR3, p(c) = 0.03; DR4, p(c) = 0.002. These findings show that: (a) DR3, a genetic marker of autoimmunity, might assist the establishment of chronic HBsAg liver disease in the absence of delta superinfection; (b) DR2 is linked with failure to clear the delta agent, and (c) DR4 may protect from virus B persistence. Identification of adventitious factors such as delta may help uncover a subgroup of HBsAg carriers who are genetically predisposed to develop chronic liver disease.

AB - The A, B, C and DR locus specificities of the human leukocyte antigens system (HLA) were determined in 45 delta-positive and 44 delta-negative Italian patients, all with HBsAg-positive chronic active liver disease; controls were 526 healthy Italian blood donors matched for age, sex and geographical origin. HLA-A, B, C gene frequencies were not significantly changed. In the delta-positive patients, the frequencies of the DR locus specificities were: DR2, 37.8%; DR3, 20%; DR4, 11.1%. In the delta-negative patients, the frequencies were: DR2, 13.6%, DR3, 36.4% DR4, 0%. Control frequencies were: DR2, 19.4%; DR3, 17.1%; DR4, 18.5%. The corrected values of the differences between controls and delta-positive patients were: DR2, p(c) = 0.046; DR3, p(c) = NS (not significant); DR4, p(c) = NS. The corrected p values of the differences between controls and delta-negative patients were: DR2, p(c) = NS; DR3, p(c) = 0.03; DR4, p(c) = 0.002. These findings show that: (a) DR3, a genetic marker of autoimmunity, might assist the establishment of chronic HBsAg liver disease in the absence of delta superinfection; (b) DR2 is linked with failure to clear the delta agent, and (c) DR4 may protect from virus B persistence. Identification of adventitious factors such as delta may help uncover a subgroup of HBsAg carriers who are genetically predisposed to develop chronic liver disease.

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