HLA-Dr+ T cells of the Leu 3 (helper) type infiltrate the kidneys of patients with systemic lupus erythematosus

F. Caligaris-Cappio; L. Bergui; L. Tesio; R. Ziano; G. Camussi

HLA-Dr+ T cells of the Leu 3 (helper) type infiltrate the kidneys of patients with systemic lupus erythematosus

F. Caligaris-Cappio, L. Bergui, L. Tesio, R. Ziano, G. Camussi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

The lineage and distribution of mononuclear cells infiltrating the kidneys of patients with systemic lupus erythematosus (SLE) have been investigated in cryostat tissue section of biopsies from 11 patients. The use of heterologous antisera and monoclonal antibodies has revealed that: (1) B lymphocytes and plasma cells are virtually absent in SLE kidney specimens; (2) The vast majority of mononuclear cells which infiltrate the interstitium are activated (HLA-Dr⁺) T cells (Leu 4⁺) presenting the helper (Leu 3⁺) phenotype; (3) T cells are absent in the glomeruli, where HLA-Dr⁺, SIgM^-, Leu 4^- elements with a macrophage like appearance can be observed.

Original language	English
Pages (from-to)	185-189
Number of pages	5
Journal	Clinical and Experimental Immunology
Volume	59
Issue number	1
Publication status	Published - 1985

ASJC Scopus subject areas

Immunology

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title = "HLA-Dr+ T cells of the Leu 3 (helper) type infiltrate the kidneys of patients with systemic lupus erythematosus",

abstract = "The lineage and distribution of mononuclear cells infiltrating the kidneys of patients with systemic lupus erythematosus (SLE) have been investigated in cryostat tissue section of biopsies from 11 patients. The use of heterologous antisera and monoclonal antibodies has revealed that: (1) B lymphocytes and plasma cells are virtually absent in SLE kidney specimens; (2) The vast majority of mononuclear cells which infiltrate the interstitium are activated (HLA-Dr+) T cells (Leu 4+) presenting the helper (Leu 3+) phenotype; (3) T cells are absent in the glomeruli, where HLA-Dr+, SIgM-, Leu 4- elements with a macrophage like appearance can be observed.",

author = "F. Caligaris-Cappio and L. Bergui and L. Tesio and R. Ziano and G. Camussi",

year = "1985",

language = "English",

volume = "59",

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T1 - HLA-Dr+ T cells of the Leu 3 (helper) type infiltrate the kidneys of patients with systemic lupus erythematosus

AU - Caligaris-Cappio, F.

AU - Bergui, L.

AU - Tesio, L.

AU - Ziano, R.

AU - Camussi, G.

PY - 1985

Y1 - 1985

N2 - The lineage and distribution of mononuclear cells infiltrating the kidneys of patients with systemic lupus erythematosus (SLE) have been investigated in cryostat tissue section of biopsies from 11 patients. The use of heterologous antisera and monoclonal antibodies has revealed that: (1) B lymphocytes and plasma cells are virtually absent in SLE kidney specimens; (2) The vast majority of mononuclear cells which infiltrate the interstitium are activated (HLA-Dr+) T cells (Leu 4+) presenting the helper (Leu 3+) phenotype; (3) T cells are absent in the glomeruli, where HLA-Dr+, SIgM-, Leu 4- elements with a macrophage like appearance can be observed.

AB - The lineage and distribution of mononuclear cells infiltrating the kidneys of patients with systemic lupus erythematosus (SLE) have been investigated in cryostat tissue section of biopsies from 11 patients. The use of heterologous antisera and monoclonal antibodies has revealed that: (1) B lymphocytes and plasma cells are virtually absent in SLE kidney specimens; (2) The vast majority of mononuclear cells which infiltrate the interstitium are activated (HLA-Dr+) T cells (Leu 4+) presenting the helper (Leu 3+) phenotype; (3) T cells are absent in the glomeruli, where HLA-Dr+, SIgM-, Leu 4- elements with a macrophage like appearance can be observed.

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