Abstract
The lineage and distribution of mononuclear cells infiltrating the kidneys of patients with systemic lupus erythematosus (SLE) have been investigated in cryostat tissue section of biopsies from 11 patients. The use of heterologous antisera and monoclonal antibodies has revealed that: (1) B lymphocytes and plasma cells are virtually absent in SLE kidney specimens; (2) The vast majority of mononuclear cells which infiltrate the interstitium are activated (HLA-Dr+) T cells (Leu 4+) presenting the helper (Leu 3+) phenotype; (3) T cells are absent in the glomeruli, where HLA-Dr+, SIgM-, Leu 4- elements with a macrophage like appearance can be observed.
| Original language | English |
|---|---|
| Pages (from-to) | 185-189 |
| Number of pages | 5 |
| Journal | Clinical and Experimental Immunology |
| Volume | 59 |
| Issue number | 1 |
| Publication status | Published - 1985 |
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- Immunology
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HLA-Dr+ T cells of the Leu 3 (helper) type infiltrate the kidneys of patients with systemic lupus erythematosus. / Caligaris-Cappio, F.; Bergui, L.; Tesio, L.; Ziano, R.; Camussi, G.
In: Clinical and Experimental Immunology, Vol. 59, No. 1, 1985, p. 185-189.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HLA-Dr+ T cells of the Leu 3 (helper) type infiltrate the kidneys of patients with systemic lupus erythematosus
AU - Caligaris-Cappio, F.
AU - Bergui, L.
AU - Tesio, L.
AU - Ziano, R.
AU - Camussi, G.
PY - 1985
Y1 - 1985
N2 - The lineage and distribution of mononuclear cells infiltrating the kidneys of patients with systemic lupus erythematosus (SLE) have been investigated in cryostat tissue section of biopsies from 11 patients. The use of heterologous antisera and monoclonal antibodies has revealed that: (1) B lymphocytes and plasma cells are virtually absent in SLE kidney specimens; (2) The vast majority of mononuclear cells which infiltrate the interstitium are activated (HLA-Dr+) T cells (Leu 4+) presenting the helper (Leu 3+) phenotype; (3) T cells are absent in the glomeruli, where HLA-Dr+, SIgM-, Leu 4- elements with a macrophage like appearance can be observed.
AB - The lineage and distribution of mononuclear cells infiltrating the kidneys of patients with systemic lupus erythematosus (SLE) have been investigated in cryostat tissue section of biopsies from 11 patients. The use of heterologous antisera and monoclonal antibodies has revealed that: (1) B lymphocytes and plasma cells are virtually absent in SLE kidney specimens; (2) The vast majority of mononuclear cells which infiltrate the interstitium are activated (HLA-Dr+) T cells (Leu 4+) presenting the helper (Leu 3+) phenotype; (3) T cells are absent in the glomeruli, where HLA-Dr+, SIgM-, Leu 4- elements with a macrophage like appearance can be observed.
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UR - http://www.scopus.com/inward/citedby.url?scp=0021990203&partnerID=8YFLogxK
M3 - Article
VL - 59
SP - 185
EP - 189
JO - Clinical and Experimental Immunology
JF - Clinical and Experimental Immunology
SN - 0009-9104
IS - 1
ER -