Alleli HLA-DRB1 e artrite reumatoide nel nord Italia: Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari

Ruggero Beri; Dimitri Peterlana; Antonio Puccetti; Sara Simeoni; Paolo Garzotti; Domenico Biasi; Paola Caramaschi; Elisa Tinazzi; Claudio Lunardi

Alleli HLA-DRB1 e artrite reumatoide nel nord Italia: Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari

Translated title of the contribution: HLA-DRB1 alleles and rheumatoid arthritis in Northern Italy: Lack of correlation with disease severity and extra-articular manifestations

Ruggero Beri, Dimitri Peterlana, Antonio Puccetti, Sara Simeoni, Paolo Garzotti, Domenico Biasi, Paola Caramaschi, Elisa Tinazzi, Claudio Lunardi

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.

Translated title of the contribution	HLA-DRB1 alleles and rheumatoid arthritis in Northern Italy: Lack of correlation with disease severity and extra-articular manifestations
Original language	Italian
Pages (from-to)	139-143
Number of pages	5
Journal	Recenti Progressi in Medicina
Volume	96
Issue number	3
Publication status	Published - Mar 2005

ASJC Scopus subject areas

Medicine(all)

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Alleli HLA-DRB1 e artrite reumatoide nel nord Italia : Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari. / Beri, Ruggero; Peterlana, Dimitri; Puccetti, Antonio; Simeoni, Sara; Garzotti, Paolo; Biasi, Domenico; Caramaschi, Paola; Tinazzi, Elisa; Lunardi, Claudio.

In: Recenti Progressi in Medicina, Vol. 96, No. 3, 03.2005, p. 139-143.

Research output: Contribution to journal › Article › peer-review

Beri, Ruggero ; Peterlana, Dimitri ; Puccetti, Antonio ; Simeoni, Sara ; Garzotti, Paolo ; Biasi, Domenico ; Caramaschi, Paola ; Tinazzi, Elisa ; Lunardi, Claudio. / Alleli HLA-DRB1 e artrite reumatoide nel nord Italia : Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari. In: Recenti Progressi in Medicina. 2005 ; Vol. 96, No. 3. pp. 139-143.

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abstract = "We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.",

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AU - Peterlana, Dimitri

AU - Puccetti, Antonio

AU - Simeoni, Sara

AU - Garzotti, Paolo

AU - Biasi, Domenico

AU - Caramaschi, Paola

AU - Tinazzi, Elisa

AU - Lunardi, Claudio

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AB - We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.

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KW - HLA-DRB1 alleles

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Alleli HLA-DRB1 e artrite reumatoide nel nord Italia: Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari

Abstract

ASJC Scopus subject areas

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