Abstract
We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.
| Original language | Italian |
|---|---|
| Pages (from-to) | 139-143 |
| Number of pages | 5 |
| Journal | Recenti Progressi in Medicina |
| Volume | 96 |
| Issue number | 3 |
| Publication status | Published - Mar 2005 |
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ASJC Scopus subject areas
- Medicine(all)
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Alleli HLA-DRB1 e artrite reumatoide nel nord Italia : Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari. / Beri, Ruggero; Peterlana, Dimitri; Puccetti, Antonio; Simeoni, Sara; Garzotti, Paolo; Biasi, Domenico; Caramaschi, Paola; Tinazzi, Elisa; Lunardi, Claudio.
In: Recenti Progressi in Medicina, Vol. 96, No. 3, 03.2005, p. 139-143.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Alleli HLA-DRB1 e artrite reumatoide nel nord Italia
T2 - Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari
AU - Beri, Ruggero
AU - Peterlana, Dimitri
AU - Puccetti, Antonio
AU - Simeoni, Sara
AU - Garzotti, Paolo
AU - Biasi, Domenico
AU - Caramaschi, Paola
AU - Tinazzi, Elisa
AU - Lunardi, Claudio
PY - 2005/3
Y1 - 2005/3
N2 - We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.
AB - We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.
KW - Extra-articular disease
KW - HLA-DRB1 alleles
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=22844450190&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22844450190&partnerID=8YFLogxK
M3 - Articolo
C2 - 15929613
AN - SCOPUS:22844450190
VL - 96
SP - 139
EP - 143
JO - Recenti Progressi in Medicina
JF - Recenti Progressi in Medicina
SN - 0034-1193
IS - 3
ER -