Alleli HLA-DRB1 e artrite reumatoide nel nord Italia: Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari

Ruggero Beri; Dimitri Peterlana; Antonio Puccetti; Sara Simeoni; Paolo Garzotti; Domenico Biasi; Paola Caramaschi; Elisa Tinazzi; Claudio Lunardi

Alleli HLA-DRB1 e artrite reumatoide nel nord Italia: Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari

Translated title of the contribution: HLA-DRB1 alleles and rheumatoid arthritis in Northern Italy: Lack of correlation with disease severity and extra-articular manifestations

Ruggero Beri, Dimitri Peterlana, Antonio Puccetti, Sara Simeoni, Paolo Garzotti, Domenico Biasi, Paola Caramaschi, Elisa Tinazzi, Claudio Lunardi

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.

Translated title of the contribution	HLA-DRB1 alleles and rheumatoid arthritis in Northern Italy: Lack of correlation with disease severity and extra-articular manifestations
Original language	Italian
Pages (from-to)	139-143
Number of pages	5
Journal	Recenti Progressi in Medicina
Volume	96
Issue number	3
Publication status	Published - Mar 2005

ASJC Scopus subject areas

Medicine(all)

Cite this

Alleli HLA-DRB1 e artrite reumatoide nel nord Italia : Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari. / Beri, Ruggero; Peterlana, Dimitri; Puccetti, Antonio; Simeoni, Sara; Garzotti, Paolo; Biasi, Domenico; Caramaschi, Paola; Tinazzi, Elisa; Lunardi, Claudio.

In: Recenti Progressi in Medicina, Vol. 96, No. 3, 03.2005, p. 139-143.

Research output: Contribution to journal › Article › peer-review

Beri, Ruggero ; Peterlana, Dimitri ; Puccetti, Antonio ; Simeoni, Sara ; Garzotti, Paolo ; Biasi, Domenico ; Caramaschi, Paola ; Tinazzi, Elisa ; Lunardi, Claudio. / Alleli HLA-DRB1 e artrite reumatoide nel nord Italia : Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari. In: Recenti Progressi in Medicina. 2005 ; Vol. 96, No. 3. pp. 139-143.

@article{a4825ac365f945d38ebc6abc13c79b61,

title = "Alleli HLA-DRB1 e artrite reumatoide nel nord Italia: Assenza di correlazione con la gravit{\`a} della malattia e con manifestazioni extra-articolari",

abstract = "We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.",

keywords = "Extra-articular disease, HLA-DRB1 alleles, Rheumatoid arthritis",

author = "Ruggero Beri and Dimitri Peterlana and Antonio Puccetti and Sara Simeoni and Paolo Garzotti and Domenico Biasi and Paola Caramaschi and Elisa Tinazzi and Claudio Lunardi",

year = "2005",

month = mar,

language = "Italian",

volume = "96",

pages = "139--143",

journal = "Recenti Progressi in Medicina",

issn = "0034-1193",

publisher = "Il Pensiero Scientifico Editore s.r.l.",

number = "3",

}

TY - JOUR

T1 - Alleli HLA-DRB1 e artrite reumatoide nel nord Italia

T2 - Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari

AU - Beri, Ruggero

AU - Peterlana, Dimitri

AU - Puccetti, Antonio

AU - Simeoni, Sara

AU - Garzotti, Paolo

AU - Biasi, Domenico

AU - Caramaschi, Paola

AU - Tinazzi, Elisa

AU - Lunardi, Claudio

PY - 2005/3

Y1 - 2005/3

N2 - We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.

AB - We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.

KW - Extra-articular disease

KW - HLA-DRB1 alleles

KW - Rheumatoid arthritis

UR - http://www.scopus.com/inward/record.url?scp=22844450190&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22844450190&partnerID=8YFLogxK

M3 - Articolo

C2 - 15929613

AN - SCOPUS:22844450190

VL - 96

SP - 139

EP - 143

JO - Recenti Progressi in Medicina

JF - Recenti Progressi in Medicina

SN - 0034-1193

IS - 3

ER -

Alleli HLA-DRB1 e artrite reumatoide nel nord Italia: Assenza di correlazione con la gravità della malattia e con manifestazioni extra-articolari

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this