Abstract
We studied HLA-DRB1 alleles in 101 patients with rheumatoid arthritis (RA) and 229 normal subjects by polymerase chain reaction and sequence-specific oligonuclotide hybridization. We observed a statistically significant association between HLA-DR4 and RA (p=0.0088). This association was not observed for the DR1 status. No particular DR4 suballeles were preferentially expressed in patients. Allele *0102 was more frequent in RA patients (p=0.0084), while *0103 in controls (p=0.000047). No difference was observed for the presence of early erosions and extra-articular features in patients with no, one or two RA associated alleles and among share epitope positive and negative patients.
Translated title of the contribution | HLA-DRB1 alleles and rheumatoid arthritis in Northern Italy: Lack of correlation with disease severity and extra-articular manifestations |
---|---|
Original language | Italian |
Pages (from-to) | 139-143 |
Number of pages | 5 |
Journal | Recenti Progressi in Medicina |
Volume | 96 |
Issue number | 3 |
Publication status | Published - Mar 2005 |
ASJC Scopus subject areas
- Medicine(all)