HLA-DRB1 donor-recipient mismatch affects the outcome of hepatitis C disease recurrence after liver transplantation

Luca Saverio Belli, Patrizia Burra, Francesca Poli, Alberto Battista Alberti, Enrico Silini, Claudio Zavaglia, Stefano Fagiuoli, Daniela Prando, Alejandro Espadas De Arias, Sara Boninsegna, Carmine Tinelli, Mario Scalamogna, Luciano De Carlis, Giovambattista Pinzello

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background & Aims: This study extends our previously reported observations that various immunological factors are associated with the occurrence of histologically proven recurrent hepatitis C. The two specific issues investigated were to confirm the associations of MHC alleles and donor/recipient mismatch with the occurrence of recurrent hepatitis C in an independent cohort of newly transplanted patients and to look for immunologic and nonimmunologic variables affecting the severity of the recurrent disease. Methods: Two separate cohorts of consecutive patients were studied: a look-back cohort (LC) of 120 patients and a cohort for studying the disease progression (CSDP) of 190 patients. Protocol liver biopsies were obtained at least 1, 3, 5, 7, and 10 years after liver transplantation (LT). Results: A fully mismatched donor/recipient pair at the DRB1 locus was confirmed to be associated with both the recurrence of histologic hepatitis in the LC (59% vs 23%, P = .0002) and its progression beyond stage 3 in the CSPD (71.4% vs 39.3%, P = .0003). Relevant immunologic and nonimmunologic variables were included into a multivariate Cox proportional model and three variables, namely, donor age, full HLA-DRB1 donor-recipient mismatch, and HLA B14, resulted in independent risk factors for the development of severe fibrosis. Conclusion: This study provides evidence that DRB1 donor-recipient mismatch affects both the occurrence and progression of recurrent hepatitis C disease. This information is clinically relevant as it may help to better allocate organs and to recognize patients at risk for progression so that specific interventions can be implemented.

Original languageEnglish
Pages (from-to)695-702
Number of pages8
JournalGastroenterology
Volume130
Issue number3
DOIs
Publication statusPublished - Mar 2006

Fingerprint

HLA-DRB1 Chains
Hepatitis C
Liver Transplantation
Recurrence
Tissue Donors
HLA-B14 Antigen
Immunologic Factors
Proportional Hazards Models
Hepatitis
Disease Progression
Fibrosis
Alleles
Biopsy
Liver

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Belli, L. S., Burra, P., Poli, F., Alberti, A. B., Silini, E., Zavaglia, C., ... Pinzello, G. (2006). HLA-DRB1 donor-recipient mismatch affects the outcome of hepatitis C disease recurrence after liver transplantation. Gastroenterology, 130(3), 695-702. https://doi.org/10.1053/j.gastro.2005.11.013

HLA-DRB1 donor-recipient mismatch affects the outcome of hepatitis C disease recurrence after liver transplantation. / Belli, Luca Saverio; Burra, Patrizia; Poli, Francesca; Alberti, Alberto Battista; Silini, Enrico; Zavaglia, Claudio; Fagiuoli, Stefano; Prando, Daniela; Espadas De Arias, Alejandro; Boninsegna, Sara; Tinelli, Carmine; Scalamogna, Mario; De Carlis, Luciano; Pinzello, Giovambattista.

In: Gastroenterology, Vol. 130, No. 3, 03.2006, p. 695-702.

Research output: Contribution to journalArticle

Belli, LS, Burra, P, Poli, F, Alberti, AB, Silini, E, Zavaglia, C, Fagiuoli, S, Prando, D, Espadas De Arias, A, Boninsegna, S, Tinelli, C, Scalamogna, M, De Carlis, L & Pinzello, G 2006, 'HLA-DRB1 donor-recipient mismatch affects the outcome of hepatitis C disease recurrence after liver transplantation', Gastroenterology, vol. 130, no. 3, pp. 695-702. https://doi.org/10.1053/j.gastro.2005.11.013
Belli, Luca Saverio ; Burra, Patrizia ; Poli, Francesca ; Alberti, Alberto Battista ; Silini, Enrico ; Zavaglia, Claudio ; Fagiuoli, Stefano ; Prando, Daniela ; Espadas De Arias, Alejandro ; Boninsegna, Sara ; Tinelli, Carmine ; Scalamogna, Mario ; De Carlis, Luciano ; Pinzello, Giovambattista. / HLA-DRB1 donor-recipient mismatch affects the outcome of hepatitis C disease recurrence after liver transplantation. In: Gastroenterology. 2006 ; Vol. 130, No. 3. pp. 695-702.
@article{73a774322ad04343b55c64fa34630c1d,
title = "HLA-DRB1 donor-recipient mismatch affects the outcome of hepatitis C disease recurrence after liver transplantation",
abstract = "Background & Aims: This study extends our previously reported observations that various immunological factors are associated with the occurrence of histologically proven recurrent hepatitis C. The two specific issues investigated were to confirm the associations of MHC alleles and donor/recipient mismatch with the occurrence of recurrent hepatitis C in an independent cohort of newly transplanted patients and to look for immunologic and nonimmunologic variables affecting the severity of the recurrent disease. Methods: Two separate cohorts of consecutive patients were studied: a look-back cohort (LC) of 120 patients and a cohort for studying the disease progression (CSDP) of 190 patients. Protocol liver biopsies were obtained at least 1, 3, 5, 7, and 10 years after liver transplantation (LT). Results: A fully mismatched donor/recipient pair at the DRB1 locus was confirmed to be associated with both the recurrence of histologic hepatitis in the LC (59{\%} vs 23{\%}, P = .0002) and its progression beyond stage 3 in the CSPD (71.4{\%} vs 39.3{\%}, P = .0003). Relevant immunologic and nonimmunologic variables were included into a multivariate Cox proportional model and three variables, namely, donor age, full HLA-DRB1 donor-recipient mismatch, and HLA B14, resulted in independent risk factors for the development of severe fibrosis. Conclusion: This study provides evidence that DRB1 donor-recipient mismatch affects both the occurrence and progression of recurrent hepatitis C disease. This information is clinically relevant as it may help to better allocate organs and to recognize patients at risk for progression so that specific interventions can be implemented.",
author = "Belli, {Luca Saverio} and Patrizia Burra and Francesca Poli and Alberti, {Alberto Battista} and Enrico Silini and Claudio Zavaglia and Stefano Fagiuoli and Daniela Prando and {Espadas De Arias}, Alejandro and Sara Boninsegna and Carmine Tinelli and Mario Scalamogna and {De Carlis}, Luciano and Giovambattista Pinzello",
year = "2006",
month = "3",
doi = "10.1053/j.gastro.2005.11.013",
language = "English",
volume = "130",
pages = "695--702",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - HLA-DRB1 donor-recipient mismatch affects the outcome of hepatitis C disease recurrence after liver transplantation

AU - Belli, Luca Saverio

AU - Burra, Patrizia

AU - Poli, Francesca

AU - Alberti, Alberto Battista

AU - Silini, Enrico

AU - Zavaglia, Claudio

AU - Fagiuoli, Stefano

AU - Prando, Daniela

AU - Espadas De Arias, Alejandro

AU - Boninsegna, Sara

AU - Tinelli, Carmine

AU - Scalamogna, Mario

AU - De Carlis, Luciano

AU - Pinzello, Giovambattista

PY - 2006/3

Y1 - 2006/3

N2 - Background & Aims: This study extends our previously reported observations that various immunological factors are associated with the occurrence of histologically proven recurrent hepatitis C. The two specific issues investigated were to confirm the associations of MHC alleles and donor/recipient mismatch with the occurrence of recurrent hepatitis C in an independent cohort of newly transplanted patients and to look for immunologic and nonimmunologic variables affecting the severity of the recurrent disease. Methods: Two separate cohorts of consecutive patients were studied: a look-back cohort (LC) of 120 patients and a cohort for studying the disease progression (CSDP) of 190 patients. Protocol liver biopsies were obtained at least 1, 3, 5, 7, and 10 years after liver transplantation (LT). Results: A fully mismatched donor/recipient pair at the DRB1 locus was confirmed to be associated with both the recurrence of histologic hepatitis in the LC (59% vs 23%, P = .0002) and its progression beyond stage 3 in the CSPD (71.4% vs 39.3%, P = .0003). Relevant immunologic and nonimmunologic variables were included into a multivariate Cox proportional model and three variables, namely, donor age, full HLA-DRB1 donor-recipient mismatch, and HLA B14, resulted in independent risk factors for the development of severe fibrosis. Conclusion: This study provides evidence that DRB1 donor-recipient mismatch affects both the occurrence and progression of recurrent hepatitis C disease. This information is clinically relevant as it may help to better allocate organs and to recognize patients at risk for progression so that specific interventions can be implemented.

AB - Background & Aims: This study extends our previously reported observations that various immunological factors are associated with the occurrence of histologically proven recurrent hepatitis C. The two specific issues investigated were to confirm the associations of MHC alleles and donor/recipient mismatch with the occurrence of recurrent hepatitis C in an independent cohort of newly transplanted patients and to look for immunologic and nonimmunologic variables affecting the severity of the recurrent disease. Methods: Two separate cohorts of consecutive patients were studied: a look-back cohort (LC) of 120 patients and a cohort for studying the disease progression (CSDP) of 190 patients. Protocol liver biopsies were obtained at least 1, 3, 5, 7, and 10 years after liver transplantation (LT). Results: A fully mismatched donor/recipient pair at the DRB1 locus was confirmed to be associated with both the recurrence of histologic hepatitis in the LC (59% vs 23%, P = .0002) and its progression beyond stage 3 in the CSPD (71.4% vs 39.3%, P = .0003). Relevant immunologic and nonimmunologic variables were included into a multivariate Cox proportional model and three variables, namely, donor age, full HLA-DRB1 donor-recipient mismatch, and HLA B14, resulted in independent risk factors for the development of severe fibrosis. Conclusion: This study provides evidence that DRB1 donor-recipient mismatch affects both the occurrence and progression of recurrent hepatitis C disease. This information is clinically relevant as it may help to better allocate organs and to recognize patients at risk for progression so that specific interventions can be implemented.

UR - http://www.scopus.com/inward/record.url?scp=33644864315&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644864315&partnerID=8YFLogxK

U2 - 10.1053/j.gastro.2005.11.013

DO - 10.1053/j.gastro.2005.11.013

M3 - Article

VL - 130

SP - 695

EP - 702

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -