HLA-G 14 bp deletion/insertion polymorphism in celiac disease

Annalisa Fabris, Ludovica Segat, Eulalia Catamo, Marcello Morgutti, Anna Vendramin, Sergio Crovella

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Nonclassical major histocompatibility class I HLA-G antigen is a tolerogenic molecule that inhibits lytic activity of natural killer (NK) cells and cytotoxic T lymphocytes. Because of its immunomodulatory and tolerogenic properties, HLA-G molecules may have a role in celiac disease (CD). We analyzed the HLA-G 14 bp deletion/insertion polymorphism, known to have a functional effect on mRNA stability, in a group of 522 CD patients, stratified for the presence of HLA-DQ2 genotype, and 400 healthy individuals to evaluate the possible effect of the polymorphism on the risk to develop the disease. Methods: HLA-G 14 bp deletion/insertion polymorphism (rs1704) was detected by polymerase chain reaction and double-checked by direct sequencing. Results: The 14bp inserted (I) allele and the homozygous I/I genotype were significantly more frequent in CD patients than in healthy controls. The presence of I allele was associated with an increased risk of CD (OR 1.35) and the effect of I allele was consistent with a recessive genetic model (P

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalAmerican Journal of Gastroenterology
Volume106
Issue number1
DOIs
Publication statusPublished - Jan 2011

ASJC Scopus subject areas

  • Gastroenterology

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