HLA-G 14bp del/ins genetic variation: Association with susceptibility to human immunodeficiency virus-1 vertical transmission but not with human immunodeficiency virus-1 infection through horizontal transmission

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Abstract

We discuss herein the possible involvement of human leukocyte antigen (HLA)-G 14bp del/ins polymorphism in human immunodeficiency virus (HIV) infection. Based on previous results and reports, we suggest that HLA-G should be considered, in the context of HIV-1 infection, as a candidate molecule for the susceptibility to HIV-1 mother-to-child transmission, rather than for HIV-1 horizontal transmission for which no consensus findings and hypothesis have been reported so far.

Original languageEnglish
Pages (from-to)12-13
Number of pages2
JournalTissue Antigens
Volume80
Issue number1
DOIs
Publication statusPublished - Jul 2012

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Virus Diseases
HLA Antigens
Viruses
HIV-1
Consensus
Polymorphism
Mothers
HIV
Molecules

Keywords

  • Genetic polymorphisms
  • Human immunodeficiency virus-1 infection
  • Human leukocyte antigen-G
  • Vertical transmission

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Genetics

Cite this

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abstract = "We discuss herein the possible involvement of human leukocyte antigen (HLA)-G 14bp del/ins polymorphism in human immunodeficiency virus (HIV) infection. Based on previous results and reports, we suggest that HLA-G should be considered, in the context of HIV-1 infection, as a candidate molecule for the susceptibility to HIV-1 mother-to-child transmission, rather than for HIV-1 horizontal transmission for which no consensus findings and hypothesis have been reported so far.",
keywords = "Genetic polymorphisms, Human immunodeficiency virus-1 infection, Human leukocyte antigen-G, Vertical transmission",
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T2 - Association with susceptibility to human immunodeficiency virus-1 vertical transmission but not with human immunodeficiency virus-1 infection through horizontal transmission

AU - Segat, L.

AU - Crovella, S.

PY - 2012/7

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N2 - We discuss herein the possible involvement of human leukocyte antigen (HLA)-G 14bp del/ins polymorphism in human immunodeficiency virus (HIV) infection. Based on previous results and reports, we suggest that HLA-G should be considered, in the context of HIV-1 infection, as a candidate molecule for the susceptibility to HIV-1 mother-to-child transmission, rather than for HIV-1 horizontal transmission for which no consensus findings and hypothesis have been reported so far.

AB - We discuss herein the possible involvement of human leukocyte antigen (HLA)-G 14bp del/ins polymorphism in human immunodeficiency virus (HIV) infection. Based on previous results and reports, we suggest that HLA-G should be considered, in the context of HIV-1 infection, as a candidate molecule for the susceptibility to HIV-1 mother-to-child transmission, rather than for HIV-1 horizontal transmission for which no consensus findings and hypothesis have been reported so far.

KW - Genetic polymorphisms

KW - Human immunodeficiency virus-1 infection

KW - Human leukocyte antigen-G

KW - Vertical transmission

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