HLA-G 3′ UTR haplotypes and HIV vertical transmission

Ludovica Segat, Eulalia Catamo, Annalisa Fabris, Lara Padovan, Marcello Morgutti, Sergio Crovella

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the possible association of human leukocyte antigen-G (HLA-G) 3777G>C and 14-bp deletion/insertion (D/I) polymorphisms haplotypes and combined genotypes with perinatal HIV transmission in Brazilian children. The 3777G>C polymorphism alone has no effect on HIV vertical transmission but, when linked with the D allele, exerts a positive role in the protection. Indeed, we identified the DC HLA-G haplotype as significantly associated with a protective effect towards HIV vertical transmission.

Original languageEnglish
Pages (from-to)1916-1918
Number of pages3
JournalAIDS (London, England)
Volume23
Issue number14
DOIs
Publication statusPublished - Sep 2009

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

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