HLA-G and anti-HCV in patients on the waiting list for kidney transplantation

Linda Sommese, Rossella Paolillo, Francesco Cacciatore, Vincenzo Grimaldi, Chiara Sabia, Antonella Esposito, Antonio Sorriento, Carmela Iannone, Nicolò Rupealta, Gerardo Sarno, Michele Santangelo, Paride De Rosa, Gianfranco Nicoletti, Claudio Napoli

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Human leukocyte antigen (HLA)-G is a non-classic major histocompatibility complex HLA class I molecule. HLA-G may have tolerogenic properties which are linked to epigenetic-sensitive pathways. There is a correlation of sHLA-G levels and graft acceptance in transplantation studies. There are previous data on correlation of sHLA-G with graft rejection as well as with viral infections such as hepatitis C virus (HCV) in kidney transplanted patients. Here, we report the sHLA-G expression in patients on the waiting list for kidney transplantation, with and without anti-HCV compared to a control group. Methods: Serum of 67 patients on the waiting list for kidney transplantation (n = 43 with anti-HCV and n = 24 without anti-HCV) was analyzed. Among these patients, n = 39 were on the waiting list for the first transplantation, while n = 28 were patients who returned in the list. The control group included n = 23 blood donors with anti-HCV (n = 13) and without anti-HCV (n = 10). Results: The expression of sHLA-G was significantly lower in the control group (39.6 ± 34.1 U/ml) compared to both - patients on the waiting list for the first transplantation (62.5 ± 42.4 U/ml, p=0.031) and patients who returned in the list (76.7 ± 53.9 U/ml, p=0.006). No significant differences were observed in all anti-HCV positive groups. A positive linear correlation between sHLA-G and TNF-α and patient age was observed. Conclusions: Serum sHLA-G values were significantly increased in both - patients on the waiting list for the first transplantation and patients who returned in the list, as compared to control group. Our findings confirm the key tolerogenic role of sHLA-G levels as epigenetic-related marker for measuring the state of kidney allograft acceptance.

Original languageEnglish
Pages (from-to)317-322
Number of pages6
JournalAdvances in Medical Sciences
Volume63
Issue number2
DOIs
Publication statusPublished - Sep 1 2018

Keywords

  • HCV
  • HLA-G
  • Kidney transplantation

ASJC Scopus subject areas

  • Medicine(all)

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