HLA-G and susceptibility to develop celiac disease

Eulalia Catamo, Luisa Zupin, Ludovica Segat, Fulvio Celsi, Sergio Crovella

Research output: Contribution to journalArticlepeer-review

Abstract

The Human Leukocyte Antigen-G has immunomodulatory function and its expression has been associated with several diseases. In our study we analyzed HLA-G polymorphisms in order to evaluate their possible association with susceptibility to celiac disease development. A total of 420 celiac patients and 509 controls were genotyped for HLA-G polymorphisms. We sequenced 800. bp upstream the ATG codon (5' upstream regulatory region) and the whole 3' untranslated region of the HLA-G gene, whereas the δC deletion at exon 3 was detected by RFLP-PCR.Five polymorphisms (namely -477 C>G, -369 C>A, 14. bp del/ins, 3187 A>G, 3196 C>G) and one haplotype (TCGGTACGAAITCCCGAG) were significantly more frequent in celiac patients than controls and associated with increased disease susceptibility. The 14. bp I/I, 3187 G/G, 3196 G/G genotypes and TCGGTACGAAITCCCGAG haplotype, were still significantly associated with increased disease susceptibility (and in addition also the 3003 C/C genotype) when the analysis was restricted to patients and controls presenting the DQ2.5 or DQ8 HLA-DQ celiac disease risk haplotypes.Our findings indicate an association between HLA-G gene polymorphisms and susceptibility to celiac disease development, suggesting that HLA-G molecule is possibly involved in the pathogenesis of the disease.

Original languageEnglish
Pages (from-to)36-41
Number of pages6
JournalHuman Immunology
Volume76
Issue number1
DOIs
Publication statusPublished - Jan 1 2015

Keywords

  • Celiac disease
  • Human Leukocyte Antigen (HLA)-G
  • Inflammation
  • MRNA stability

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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