HLA-G in organ transplantation: Towards clinical applications

Frederic Deschaseaux, Diego Delgado, Vito Pistoia, Massimo Giuliani, Fabio Morandi, Antoine Durrbach

Research output: Contribution to journalArticlepeer-review

Abstract

HLA-G plays a particular role during pregnancy in which its expression at the feto-maternal barrier participates into the tolerance of the allogenic foetus. HLA-G has also been demonstrated to be expressed in some transplanted patients, suggesting that it regulates the allogenic response. In vitro data indicate that HLA-G modulates NK cells, T cells, and DC maturation through its interactions with various inhibitory receptors. In this paper, we will review the data reporting the HLA-G involvement of HLA-G in human organ transplantation, then factors that can modulate HLA-G, and finally the use of HLA-G as a therapeutic tool in organ transplantation.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalCellular and Molecular Life Sciences
Volume68
Issue number3
DOIs
Publication statusPublished - Feb 2011

Keywords

  • HLA-G
  • Immunoregulation
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

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