HLA-G/C, miRNAs, and their role in HIV infection and replication

Fulvio Celsi, Eulalia Catamo, Giulio Kleiner, Paola Maura Tricarico, Josef Vuch, Sergio Crovella

Research output: Contribution to journalArticle

Abstract

In recent years, a number of different mechanisms regulating gene expressions, either in normal or in pathological conditions, have been discovered. This review aims to highlight some of the regulatory pathways involved during the HIV-1 infection and disease progression, focusing on the novel discovered microRNAs (miRNAs) and their relation with immune system's agents. Human leukocyte antigen (HLA) family of proteins plays a key role because it is a crucial modulator of the immune response; here we will examine recent findings, centering especially on HLA-C and -G, novel players lately discovered to engage in modulation of immune system. We hope to provide novel perspectives useful to find out original therapeutic roads against HIV-1 infection and AIDS progression.

Original languageEnglish
Article number693643
JournalBioMed Research International
Volume2013
DOIs
Publication statusPublished - 2013

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

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