HLA polymorphisms in Italian children with autism spectrum disorders: Results of a family based linkage study

Franca R. Guerini, Elisabetta Bolognesi, Matteo Chiappedi, Annalisa De Silvestri, Alessandro Ghezzo, Michela Zanette, Beatrice Rusconi, Salvatorica Manca, Stefano Sotgiu, Cristina Agliardi, Mario Clerici

Research output: Contribution to journalArticle

Abstract

To verify correlations between HLA and autism spectrum disorders (ASD) we studied 61 Italian families with an ASD child; results showed such correlation in 65% of cases. Case-control and TDT analysis of intrafamilial transmission of SNPs, Msats, and HLA markers surrounding the α and β blocks, indicated significant positive associations for MOGc*131 and D6S2239*105 alleles in ASD, and a negative association of MIB *332 allele in healthy siblings. Polymorphism haplotype analysis demonstrated that two haplotypes comprising the TNF-238(G)-TNF-308(G)-MIB*332-HLA-B*38-HLA-Cw*12 and the D6S265*218-HLA-A*23-MOGc*131-rs2857766(G) alleles are more frequently transmitted to ASD. MOGc and MIB loci are linked with ASD in Italian patients.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalJournal of Neuroimmunology
Volume230
Issue number1-2
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Autistic spectrum disorder
  • Family based study
  • MHC
  • Microsatellite
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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