HLA system, psychiatry and psychopharmacology

C. L. Cazzullo, E. Smeraldi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

1. 1. A number of antigens of the HLA system showed significant associations with clinical phenotypes of schizophrenia and manic depressive disorders. Even though we emphasize the need to consider these results with caution, we suggest that the Findings now available indicate that the chromosomal regions which control the HLA system also contain the genetic material related to schizophrenia. On the other hand, although initial results have been encouraging, more work is needed before we can draw definite conclusions about the relationships between HLA antigens and the genetics of manic depressive disorders. All this recently acquired information is discussed and new lines for research are also suggested, including linkage studies in families, which might offer a more precise understanding of the genetic contribution to psychopathology. 2. 2. Stressed also is the possibility that HLA determinants interfere with the interaction between neurotransmitters and/or psychotropic drugs and specific receptors. In this light, the clinical implications of HLA-A1 reactions to chlorpromazine and haloperidol, and of the HLA-A1 cross-reacting antigens are analyzed. Such studies are as yet very preliminary; however they perhaps help to clarify both the real biological roles of these antigenic membrane structures and the mechanisms by which psychotropic drugs interact with membrane receptors.

Original languageEnglish
Pages (from-to)137-146
Number of pages10
JournalProgress in Neuro-Psychopharmacology
Volume3
Issue number1-3
DOIs
Publication statusPublished - 1979

Fingerprint

HLA-A1 Antigen
Psychopharmacology
Psychotropic Drugs
Depressive Disorder
Bipolar Disorder
Psychiatry
Schizophrenia
Drug Receptors
HLA-A Antigens
Membranes
Chlorpromazine
Haloperidol
HLA Antigens
Psychopathology
Neurotransmitter Agents
Phenotype
Antigens
Research
Genes

Keywords

  • affective disorders
  • chlorpromazine
  • genetic markers
  • HLA system
  • schizophrenial

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Medicine(all)

Cite this

HLA system, psychiatry and psychopharmacology. / Cazzullo, C. L.; Smeraldi, E.

In: Progress in Neuro-Psychopharmacology, Vol. 3, No. 1-3, 1979, p. 137-146.

Research output: Contribution to journalArticle

Cazzullo, C. L. ; Smeraldi, E. / HLA system, psychiatry and psychopharmacology. In: Progress in Neuro-Psychopharmacology. 1979 ; Vol. 3, No. 1-3. pp. 137-146.
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