Hla typing and affective disorders: A study in the italian population

E. Smeraldi, F. Negri, A. M. Melica, R. Scorza-Smeraldi, G. Fabio, P. Bonara, L. Bellodi, E. Sacchetti, M. G. Sabbadini-Villa, C. L. Cazzullo, C. Zanussi

Research output: Contribution to journalArticle

Abstract

HLA phenotype distribution was investigated in 91 affective patients. Significant increases over those of the control population were found in HLA-A 29 and in Bw 22 frequencies, while A 10 and A 30 were decreased. No significant difference was shown between the two clinical subgroups (41 unipolar patients and SO bipolar ones). On comparing our data with those from other authors, Bw 16 was significantly increased. However, a high degree of heterogeneity was also shown for this antigen. Of some interest is the finding that relapsed and non-relapsed patients during long-term lithium therapy display diverging HLA phenotype distributions, with B 5 increased among the non-relapsed subjects.

Original languageEnglish
Pages (from-to)344-352
Number of pages9
JournalNeuropsychobiology
Volume4
Issue number6
DOIs
Publication statusPublished - 1978

Keywords

  • Affective disorders
  • HLA antigens

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

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  • Cite this

    Smeraldi, E., Negri, F., Melica, A. M., Scorza-Smeraldi, R., Fabio, G., Bonara, P., Bellodi, L., Sacchetti, E., Sabbadini-Villa, M. G., Cazzullo, C. L., & Zanussi, C. (1978). Hla typing and affective disorders: A study in the italian population. Neuropsychobiology, 4(6), 344-352. https://doi.org/10.1159/000117650