HMG proteins: Dynamic players in gene regulation and differentiation

Research output: Contribution to journalArticle

Abstract

Core histones package the genome into nucleosomes and control its accessibility to transcription factors. High mobility group proteins (HMGs) are, after histones, the second most abundant chromatin proteins and exert global genomic functions in establishing active or inactive chromatin domains. It is becoming increasingly clear that they also specifically control the expression of a limited number of genes. Moreover, they contribute to the fine tuning of transcription in response to rapid environmental changes. They do so by interacting with nucleosomes, transcription factors, nucleosome-remodelling machines, and with histone H1.

Original languageEnglish
Pages (from-to)496-506
Number of pages11
JournalCurrent Opinion in Genetics and Development
Volume15
Issue number5 SPEC. ISS.
DOIs
Publication statusPublished - Oct 2005

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'HMG proteins: Dynamic players in gene regulation and differentiation'. Together they form a unique fingerprint.

  • Cite this