TY - JOUR
T1 - HMGA1 protein overexpression in human breast carcinomas
T2 - Correlation with ErbB2 expression
AU - Chiappetta, Gennaro
AU - Botti, Gerardo
AU - Monaco, Mario
AU - Pasquinelli, Rosa
AU - Pentimalli, Francesca
AU - Di Bonito, Maurizio
AU - D'Aiuto, Giuseppe
AU - Fedele, Monica
AU - Iuliano, Rodolfo
AU - Palmieri, Emiliano A.
AU - Pierantoni, Giovanna Maria
AU - Giancotti, Yinceazo
AU - Fusco, Alfredo
PY - 2004/12/15
Y1 - 2004/12/15
N2 - We measured, by immunohistocheinistry, HMGA1 protein expression in 212 breast tissue specimens: 6 normal samples, 28 hyperplastic lesions (13 with cellular atypia), 11 fibroadenoinas, 10 in situ ductal carcinomas, 144 ductal carcinomas, and 13 lobular carcinomas. HMGA1 was not expressed in normal breast tissue; HMGA1 staining was intense in 40% of hyperplastic lesions with cellular atypia and in 60% of ductal carcinomas and weak in fibroadenomas and in hyperpiastic lesions without cellular atypia. Because HMGA1 expression was similar among ductal breast carcinomas with different histologic grading, we evaluated the association between HMGA1 expression and that of other markers of breast carcinoma invasion (estrogen and progesterone receptors, Ki-67 antigen, and ErbB2) in 21 cases of grade 3 breast ductal carcinomas and 7 cases of breast lobular carcinomas. We found that HMGA1 expression tended to be associated only with c-erbB-2 expression (Spearman rho: 0.36; P = 0.065). Taken together, these results suggest that HMGA1 expression might be a novel indicator for the diagnosis and prognosis of human breast cancer.
AB - We measured, by immunohistocheinistry, HMGA1 protein expression in 212 breast tissue specimens: 6 normal samples, 28 hyperplastic lesions (13 with cellular atypia), 11 fibroadenoinas, 10 in situ ductal carcinomas, 144 ductal carcinomas, and 13 lobular carcinomas. HMGA1 was not expressed in normal breast tissue; HMGA1 staining was intense in 40% of hyperplastic lesions with cellular atypia and in 60% of ductal carcinomas and weak in fibroadenomas and in hyperpiastic lesions without cellular atypia. Because HMGA1 expression was similar among ductal breast carcinomas with different histologic grading, we evaluated the association between HMGA1 expression and that of other markers of breast carcinoma invasion (estrogen and progesterone receptors, Ki-67 antigen, and ErbB2) in 21 cases of grade 3 breast ductal carcinomas and 7 cases of breast lobular carcinomas. We found that HMGA1 expression tended to be associated only with c-erbB-2 expression (Spearman rho: 0.36; P = 0.065). Taken together, these results suggest that HMGA1 expression might be a novel indicator for the diagnosis and prognosis of human breast cancer.
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U2 - 10.1158/1078-0432.CCR-04-0291
DO - 10.1158/1078-0432.CCR-04-0291
M3 - Article
C2 - 15569996
AN - SCOPUS:9344230370
VL - 10
SP - 7637
EP - 7644
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 22
ER -