HMGA1-pseudogene expression is induced in human pituitary tumors

Francesco Esposito, Marco De Martino, Daniela D’Angelo, Paula Mussnich, Gerald Raverot, Marie Lise Jaffrain-Rea, Filippo Fraggetta, Jacqueline Trouillas, Alfredo Fusco

Research output: Contribution to journalArticle

Abstract

Numerous studies have established that High Mobility Group A (HMGA) proteins play a pivotal role on the onset of human pituitary tumors. They are overexpressed in pituitary tumors, and, consistently, transgenic mice overexpressing either the Hmga1 or the Hmga2 gene develop pituitary tumors. In contrast with HMGA2, HMGA1 overexpression is not related to any rearrangement or amplification of the HMGA1 locus in these tumors. We have recently identified 2 HMGA1 pseudogenes, HMGA1P6 and HMGA1P7, acting as competitive endogenous RNA decoys for HMGA1 and other cancer related genes. Here, we show that HMGA1 pseudogene expression significantly correlates with HMGA1 mRNA levels in growth hormone and nonfunctioning pituitary adenomas likely inhibiting the repression of HMGA1 through microRNAs action. According to our functional studies, these HMGA1 pseudogenes enhance the proliferation and migration of the mouse pituitary tumor cell line, at least in part, through their upregulation. Our results point out that the overexpression of HMGA1P6 and HMGA1P7 could contribute to increase HMGA1 levels in human pituitary tumors, and then to pituitary tumorigenesis.

Original languageEnglish
Article numberA1471
Pages (from-to)1471-1475
Number of pages5
JournalCell Cycle
Volume14
Issue number9
DOIs
Publication statusPublished - 2015

Keywords

  • ceRNA
  • HMGA1
  • HMGA1P6
  • HMGA1P7
  • miRNA

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

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  • Cite this

    Esposito, F., De Martino, M., D’Angelo, D., Mussnich, P., Raverot, G., Jaffrain-Rea, M. L., Fraggetta, F., Trouillas, J., & Fusco, A. (2015). HMGA1-pseudogene expression is induced in human pituitary tumors. Cell Cycle, 14(9), 1471-1475. [A1471]. https://doi.org/10.1080/15384101.2015.1021520