HMGA1-pseudogenes and cancer

Marco De Martino, Floriana Forzati, Claudio Arra, Alfredo Fusco, Francesco Esposito

Research output: Contribution to journalArticlepeer-review

Abstract

Pseudogenes are DNA sequences with high homology to the corresponding functional gene, but, because of the accumulation of various mutations, they have lost their initial functions to code for proteins. Consequently, pseudogenes have been considered until few years ago dysfunctional relatives of the corresponding ancestral genes, and then useless in the course of genome evolution. However, several studies have recently established that pseudogenes are owners of key biological functions. Indeed, some pseudogenes control the expression of functional genes by competitively binding to the miRNAs, some of them generate small interference RNAs to negatively modulate the expression of functional genes, and some of them even encode functional mutated proteins. Here, we concentrate our attention on the pseudogenes of the HMGA1 gene, that codes for the HMGA1a and HMGA1b proteins having a critical role in development and cancer progression. In this review, we analyze the family of HMGA1 pseudogenes through three aspects: classification, characterization, and their possible function and involvement in cancer.

Original languageEnglish
Pages (from-to)28724-28735
Number of pages12
JournalOncotarget
Volume7
Issue number19
DOIs
Publication statusPublished - May 10 2016

Keywords

  • Cancer
  • CeRNA
  • HMGA
  • Pseudogenes

ASJC Scopus subject areas

  • Oncology

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