HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia.

Giovanna Maria Pierantoni, Basilia Santulli, Irene Caliendo, Francesca Pentimalli, Gennaro Chiappetta, Nicola Zanesi, Massimo Santoro, Florencia Bulrich, Alfredo Fusco

Research output: Contribution to journalArticle

Abstract

We report the first case of acute lymphoblastic leukemia associated with a t(9;12)(p22;q14) translocation within the HMGA2 locus. The breakpoint lies in the 5' region. Fluorescence in situ hybridization with a BAC clone covering the 5' region produced three signals versus two signals with a BAC clone covering the 3' region including intron 3 of HMGA2, which harbors most of the breakpoints described in benign mesenchymal tumors. HMGA2 locus rearrangement was associated with overexpression of an HMGA2 mRNA that lacked a carboxy-terminal tail. These results suggest that the HMGA2 gene rearrangement may contribute to the malignancy in leukemias harboring a 12q translocation.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalInternational Journal of Oncology
Volume23
Issue number2
Publication statusPublished - Aug 2003

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Pierantoni, G. M., Santulli, B., Caliendo, I., Pentimalli, F., Chiappetta, G., Zanesi, N., Santoro, M., Bulrich, F., & Fusco, A. (2003). HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia. International Journal of Oncology, 23(2), 363-367.