HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia.

Giovanna Maria Pierantoni, Basilia Santulli, Irene Caliendo, Francesca Pentimalli, Gennaro Chiappetta, Nicola Zanesi, Massimo Santoro, Florencia Bulrich, Alfredo Fusco

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We report the first case of acute lymphoblastic leukemia associated with a t(9;12)(p22;q14) translocation within the HMGA2 locus. The breakpoint lies in the 5' region. Fluorescence in situ hybridization with a BAC clone covering the 5' region produced three signals versus two signals with a BAC clone covering the 3' region including intron 3 of HMGA2, which harbors most of the breakpoints described in benign mesenchymal tumors. HMGA2 locus rearrangement was associated with overexpression of an HMGA2 mRNA that lacked a carboxy-terminal tail. These results suggest that the HMGA2 gene rearrangement may contribute to the malignancy in leukemias harboring a 12q translocation.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalInternational Journal of Oncology
Volume23
Issue number2
Publication statusPublished - Aug 2003

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clone Cells
Gene Rearrangement
Fluorescence In Situ Hybridization
Introns
Neoplasms
Leukemia
Messenger RNA

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pierantoni, G. M., Santulli, B., Caliendo, I., Pentimalli, F., Chiappetta, G., Zanesi, N., ... Fusco, A. (2003). HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia. International Journal of Oncology, 23(2), 363-367.

HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia. / Pierantoni, Giovanna Maria; Santulli, Basilia; Caliendo, Irene; Pentimalli, Francesca; Chiappetta, Gennaro; Zanesi, Nicola; Santoro, Massimo; Bulrich, Florencia; Fusco, Alfredo.

In: International Journal of Oncology, Vol. 23, No. 2, 08.2003, p. 363-367.

Research output: Contribution to journalArticle

Pierantoni, GM, Santulli, B, Caliendo, I, Pentimalli, F, Chiappetta, G, Zanesi, N, Santoro, M, Bulrich, F & Fusco, A 2003, 'HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia.', International Journal of Oncology, vol. 23, no. 2, pp. 363-367.
Pierantoni GM, Santulli B, Caliendo I, Pentimalli F, Chiappetta G, Zanesi N et al. HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia. International Journal of Oncology. 2003 Aug;23(2):363-367.
Pierantoni, Giovanna Maria ; Santulli, Basilia ; Caliendo, Irene ; Pentimalli, Francesca ; Chiappetta, Gennaro ; Zanesi, Nicola ; Santoro, Massimo ; Bulrich, Florencia ; Fusco, Alfredo. / HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia. In: International Journal of Oncology. 2003 ; Vol. 23, No. 2. pp. 363-367.
@article{f9f4bab1145d4448adca72170fe17e08,
title = "HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia.",
abstract = "We report the first case of acute lymphoblastic leukemia associated with a t(9;12)(p22;q14) translocation within the HMGA2 locus. The breakpoint lies in the 5' region. Fluorescence in situ hybridization with a BAC clone covering the 5' region produced three signals versus two signals with a BAC clone covering the 3' region including intron 3 of HMGA2, which harbors most of the breakpoints described in benign mesenchymal tumors. HMGA2 locus rearrangement was associated with overexpression of an HMGA2 mRNA that lacked a carboxy-terminal tail. These results suggest that the HMGA2 gene rearrangement may contribute to the malignancy in leukemias harboring a 12q translocation.",
author = "Pierantoni, {Giovanna Maria} and Basilia Santulli and Irene Caliendo and Francesca Pentimalli and Gennaro Chiappetta and Nicola Zanesi and Massimo Santoro and Florencia Bulrich and Alfredo Fusco",
year = "2003",
month = "8",
language = "English",
volume = "23",
pages = "363--367",
journal = "International Journal of Oncology",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "2",

}

TY - JOUR

T1 - HMGA2 locus rearrangement in a case of acute lymphoblastic leukemia.

AU - Pierantoni, Giovanna Maria

AU - Santulli, Basilia

AU - Caliendo, Irene

AU - Pentimalli, Francesca

AU - Chiappetta, Gennaro

AU - Zanesi, Nicola

AU - Santoro, Massimo

AU - Bulrich, Florencia

AU - Fusco, Alfredo

PY - 2003/8

Y1 - 2003/8

N2 - We report the first case of acute lymphoblastic leukemia associated with a t(9;12)(p22;q14) translocation within the HMGA2 locus. The breakpoint lies in the 5' region. Fluorescence in situ hybridization with a BAC clone covering the 5' region produced three signals versus two signals with a BAC clone covering the 3' region including intron 3 of HMGA2, which harbors most of the breakpoints described in benign mesenchymal tumors. HMGA2 locus rearrangement was associated with overexpression of an HMGA2 mRNA that lacked a carboxy-terminal tail. These results suggest that the HMGA2 gene rearrangement may contribute to the malignancy in leukemias harboring a 12q translocation.

AB - We report the first case of acute lymphoblastic leukemia associated with a t(9;12)(p22;q14) translocation within the HMGA2 locus. The breakpoint lies in the 5' region. Fluorescence in situ hybridization with a BAC clone covering the 5' region produced three signals versus two signals with a BAC clone covering the 3' region including intron 3 of HMGA2, which harbors most of the breakpoints described in benign mesenchymal tumors. HMGA2 locus rearrangement was associated with overexpression of an HMGA2 mRNA that lacked a carboxy-terminal tail. These results suggest that the HMGA2 gene rearrangement may contribute to the malignancy in leukemias harboring a 12q translocation.

UR - http://www.scopus.com/inward/record.url?scp=0345374898&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345374898&partnerID=8YFLogxK

M3 - Article

C2 - 12851685

AN - SCOPUS:0345374898

VL - 23

SP - 363

EP - 367

JO - International Journal of Oncology

JF - International Journal of Oncology

SN - 1019-6439

IS - 2

ER -