HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias

Gennaro Chiappetta, Angelo Ferraro, Emilia Vuttariello, Mario Monaco, Francesca Galdiero, Veronica De Simone, Daniela Califano, Pierlorenzo Pallante, Gerardo Botti, Luciano Pezzullo, Giovanna Maria Pierantoni, Massimo Santoro, Alfredo Fusco

Research output: Contribution to journalArticlepeer-review

Abstract

We have analysed the expression of the HMGA2 gene in a panel of normal and neoplastic thyroid tissues by immunohistochemistry and quantitative RT-PCR. HMGA2 protein was detectable in four out of 21 follicular carcinomas, 30 out of 45 papillary carcinomas, and 11 out of 12 undifferentiated carcinomas. As far as follicular thyroid adenomas are concerned, only three cases of the 31 analysed showed HMGA2 protein expression, whereas it was absent in seven normal thyroid tissues and in 12 hyperplastic nodules. Quantitative RT-PCR showed that almost all the papillary thyroid carcinomas and 13 out of 16 follicular thyroid carcinomas express much higher HMGA2 specific mRNA levels in comparison to normal thyroids and adenomas. Therefore, our data support the quantitative RT-PCR analysis of HMGA2 expression, rather than immunohistochemistry, as a powerful tool for the diagnosis of thyroid neoplasias.

Original languageEnglish
Pages (from-to)1015-1021
Number of pages7
JournalEuropean Journal of Cancer
Volume44
Issue number7
DOIs
Publication statusPublished - May 2008

Keywords

  • Carcinoma
  • HMGA2
  • Thyroid carcinogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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