HMGB1: a two-headed signal regulating tumor progression and immunity

Lara Campana, Lidia Bosurgi, Patrizia Rovere-Querini

Research output: Contribution to journalArticle

Abstract

Cells of the innate immune system sense tissue damage recognizing in the extracellular environment bona fide intracellular moieties, like high mobility group box 1 (HMGB1). In the case of tumors, HMGB1 recognition has a paradoxical dual effect: it promotes tumor neoangiogenesis and triggers protective anti-neoplastic T-cell responses. Recent advances in the study of HMGB1 have identified candidate molecular mechanisms underlying these apparently contrasting outcomes. A surprising role for innate receptors, including toll like receptor 4 (TLR4), in the response to conventional cancer radio and chemotherapy has also recently emerged, providing new insight into the mechanisms by which these treatments actually work.

Original languageEnglish
Pages (from-to)518-523
Number of pages6
JournalCurrent Opinion in Immunology
Volume20
Issue number5
DOIs
Publication statusPublished - Oct 2008

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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