HMGI-C gene expression is not required for in vivo thyroid cell transformation

Stefania Scala, Giuseppe Portella, Donatella Vitagliano, Catherine Ledent, Gennaro Chiapetta, Vincenzo Giancotti, Jacques Dumont, Alfredo Fusco

Research output: Contribution to journalArticle

Abstract

We have previously demonstrated that HMGI proteins are required for the transformation of rat thyroid cells by v-mos and v-ras-Ki oncogenes. To determine whether HMGI proteins are also required for in vivo thyroid carcinogenesis, mice carrying a disrupted HMGI-C gene (pygmy mice) were either treated with radioactive iodine or crossed with transgenic mice carrying the E7 papilloma virus oncogene under the transcriptional control of thyroglobulin gene promoter. The pygmy mice developed thyroid carcinomas with the same frequency as occurred in wild-type mice without significant macroscopic and microscopic differences. Therefore, these results indicate that HMGI-C gene expression is not required in in vivo thyroid cell malignant transformation.

Original languageEnglish
Pages (from-to)251-256
Number of pages6
JournalCarcinogenesis
Volume22
Issue number2
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Cancer Research

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  • Cite this

    Scala, S., Portella, G., Vitagliano, D., Ledent, C., Chiapetta, G., Giancotti, V., Dumont, J., & Fusco, A. (2001). HMGI-C gene expression is not required for in vivo thyroid cell transformation. Carcinogenesis, 22(2), 251-256.