HMPAO SPECT imaging of Alzheimer's disease patients with similar content-specific autobiographic delusion: Comparison using statistical parametric mapping

R. T. Staff, A. Venneri, H. G. Gemmell, M. F. Shanks, S. J. Pestell, A. D. Murray

Research output: Contribution to journalArticle

Abstract

Delusional behavior and thinking are common symptoms in Alzheimer's disease (AD). In the past, these delusions have been considered to be psychotic complications of global neurologic dysfunction. Recently, authors have suggested that content-specific delusions in AD are associated with discrete regional abnormalities of the right hemisphere. Methods: This study compared 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT images of a group of AD patients with a similar autobiographic delusion with a group of AD patients without delusions and a group of AD patients with a range of delusions but without autobiographic content. The reconstructed SPECT data were compared using a statistical parametric mapping technique. Results: The autobiographic AD group had a significant area of hypoperfusion in the right frontal lobe when compared with the 2 other groups. The area of hypoperfusion included parts of Brodmann's areas 9 and 10. Region 9 has been identified previously as having a role in episodic memory retrieval. Conclusion: This result suggests that autobiographic delusions in AD may have an identifiable neuropsychologic mechanism and that it may be possible to identify an organic cause in some patients using 99mTc-HMPAO SPECT.

Original languageEnglish
Pages (from-to)1451-1455
Number of pages5
JournalJournal of Nuclear Medicine
Volume41
Issue number9
Publication statusPublished - 2000

Fingerprint

Oximes
Delusions
Single-Photon Emission-Computed Tomography
Alzheimer Disease
Episodic Memory
Frontal Lobe
Neurologic Manifestations

Keywords

  • Alzheimer's disease delusions
  • SPECT
  • Statistical parametric mapping

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

HMPAO SPECT imaging of Alzheimer's disease patients with similar content-specific autobiographic delusion : Comparison using statistical parametric mapping. / Staff, R. T.; Venneri, A.; Gemmell, H. G.; Shanks, M. F.; Pestell, S. J.; Murray, A. D.

In: Journal of Nuclear Medicine, Vol. 41, No. 9, 2000, p. 1451-1455.

Research output: Contribution to journalArticle

Staff, R. T. ; Venneri, A. ; Gemmell, H. G. ; Shanks, M. F. ; Pestell, S. J. ; Murray, A. D. / HMPAO SPECT imaging of Alzheimer's disease patients with similar content-specific autobiographic delusion : Comparison using statistical parametric mapping. In: Journal of Nuclear Medicine. 2000 ; Vol. 41, No. 9. pp. 1451-1455.
@article{9345834cc93e4b019b9650581a9406d5,
title = "HMPAO SPECT imaging of Alzheimer's disease patients with similar content-specific autobiographic delusion: Comparison using statistical parametric mapping",
abstract = "Delusional behavior and thinking are common symptoms in Alzheimer's disease (AD). In the past, these delusions have been considered to be psychotic complications of global neurologic dysfunction. Recently, authors have suggested that content-specific delusions in AD are associated with discrete regional abnormalities of the right hemisphere. Methods: This study compared 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT images of a group of AD patients with a similar autobiographic delusion with a group of AD patients without delusions and a group of AD patients with a range of delusions but without autobiographic content. The reconstructed SPECT data were compared using a statistical parametric mapping technique. Results: The autobiographic AD group had a significant area of hypoperfusion in the right frontal lobe when compared with the 2 other groups. The area of hypoperfusion included parts of Brodmann's areas 9 and 10. Region 9 has been identified previously as having a role in episodic memory retrieval. Conclusion: This result suggests that autobiographic delusions in AD may have an identifiable neuropsychologic mechanism and that it may be possible to identify an organic cause in some patients using 99mTc-HMPAO SPECT.",
keywords = "Alzheimer's disease delusions, SPECT, Statistical parametric mapping",
author = "Staff, {R. T.} and A. Venneri and Gemmell, {H. G.} and Shanks, {M. F.} and Pestell, {S. J.} and Murray, {A. D.}",
year = "2000",
language = "English",
volume = "41",
pages = "1451--1455",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "9",

}

TY - JOUR

T1 - HMPAO SPECT imaging of Alzheimer's disease patients with similar content-specific autobiographic delusion

T2 - Comparison using statistical parametric mapping

AU - Staff, R. T.

AU - Venneri, A.

AU - Gemmell, H. G.

AU - Shanks, M. F.

AU - Pestell, S. J.

AU - Murray, A. D.

PY - 2000

Y1 - 2000

N2 - Delusional behavior and thinking are common symptoms in Alzheimer's disease (AD). In the past, these delusions have been considered to be psychotic complications of global neurologic dysfunction. Recently, authors have suggested that content-specific delusions in AD are associated with discrete regional abnormalities of the right hemisphere. Methods: This study compared 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT images of a group of AD patients with a similar autobiographic delusion with a group of AD patients without delusions and a group of AD patients with a range of delusions but without autobiographic content. The reconstructed SPECT data were compared using a statistical parametric mapping technique. Results: The autobiographic AD group had a significant area of hypoperfusion in the right frontal lobe when compared with the 2 other groups. The area of hypoperfusion included parts of Brodmann's areas 9 and 10. Region 9 has been identified previously as having a role in episodic memory retrieval. Conclusion: This result suggests that autobiographic delusions in AD may have an identifiable neuropsychologic mechanism and that it may be possible to identify an organic cause in some patients using 99mTc-HMPAO SPECT.

AB - Delusional behavior and thinking are common symptoms in Alzheimer's disease (AD). In the past, these delusions have been considered to be psychotic complications of global neurologic dysfunction. Recently, authors have suggested that content-specific delusions in AD are associated with discrete regional abnormalities of the right hemisphere. Methods: This study compared 99mTc-hexamethyl propyleneamine oxime (HMPAO) SPECT images of a group of AD patients with a similar autobiographic delusion with a group of AD patients without delusions and a group of AD patients with a range of delusions but without autobiographic content. The reconstructed SPECT data were compared using a statistical parametric mapping technique. Results: The autobiographic AD group had a significant area of hypoperfusion in the right frontal lobe when compared with the 2 other groups. The area of hypoperfusion included parts of Brodmann's areas 9 and 10. Region 9 has been identified previously as having a role in episodic memory retrieval. Conclusion: This result suggests that autobiographic delusions in AD may have an identifiable neuropsychologic mechanism and that it may be possible to identify an organic cause in some patients using 99mTc-HMPAO SPECT.

KW - Alzheimer's disease delusions

KW - SPECT

KW - Statistical parametric mapping

UR - http://www.scopus.com/inward/record.url?scp=0033801377&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033801377&partnerID=8YFLogxK

M3 - Article

C2 - 10994722

AN - SCOPUS:0033801377

VL - 41

SP - 1451

EP - 1455

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 9

ER -