In the initial stages of cancer, tumor development and cell growth largely depend on external signals from the microenvironment. Inflammatory cells and soluble mediators such as cytokines and chemokines are the main microenvironmental factors that are involved in tumor cell migration and invasion, disease progression and angiogenesis. However, beyond these abnormalities, the relationships between lymphomas and their microenvironment appear to follow a pathogenetic pattern: an independent, largely autonomous pattern (Burkitt lymphoma); a pattern dependent on deregulated interactions (Hodgkin lymphoma); or a pattern dependent on regulated coexistence (HCV-associated marginal zone lymphomas and mucosa-associated lymphoid tissue lymphomas). This book is comprised of chapters written by distinguished authors from international academic institutions and cancer research centers, aiming to highlight the relevant role of the tumor microenvironment that has recently emerged in hematolymphoid malignancies. Volume 1 covers topics including microenvironment abnormalities, lymphoma proteomics, and the various treatment options currently available.
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