Hodgkin disease survival in Europe and the U.S. Prognostic significance of morphologic groups

Claudia Allemani, Milena Sant, Roberta De Angelis, Rafael Marcos-Gragera, Jan Willem Coebergh, W. Oberaigner, H. H. Storm, T. Aareleid, M. Jechova, M. Rousarova, T. Hakulinen, G. Hedelin, I. Tron, E. Le Gall, G. Launoy, J. Mace-Lesec'h, J. Faivre, G. Chaplain, P. M. Carli, A. DanzonB. Tretarre, M. Colonna, B. Lacour, N. Raverdy, C. Berger, B. Freycon, P. Grosclaude, J. Esteve, P. Kaatsch, H. Ziegler, D. Holzel, G. Schubert Fritschle, L. Tryggvadottir, F. Berrino, P. Baili, L. Ciccolallo, P. Crosignani, G. Gatta, A. Micheli, E. Taussig, S. Sowe, S. Ferretti, E. Conti, M. Vercelli, A. Quaglia, F. Pannelli, M. Federico, M. E. Artioli, M. Ponz De Leon, P. Benatti, V. De Lisi, L. Servente, R. Zanetti, S. Patriarca, C. Magnani, G. Pastore, L. Gafa, R. Tumino, F. Falcini, M. Budroni, E. Paci, E. Crocetti, P. Zambon, S. Guzzinati, R. Capocaccia, E. Carrani, P. Roazzi, M. Santaquilani, A. Tavilla, F. Valente, A. Verdecchia, M. Delmas, F. Langmark, A. Andersen, J. Rachtan, M. Bielska-Lasota, Z. Wronkowski, I. Plesko, A. Obsitnikova, V. Pompe-Kirn, I. Izarzugaza, C. Martinez-Garcia, I. Garau, C. Navarro, M. D. Chirlaque, E. Ardanaz, C. Moreno, J. Galceran, A. Torrella, R. Peris-Bonet, L. Barlow, T. Moller, G. Jundt, J. M. Lutz, C. Bouchardy, A. Van Der Does-Van Den Berg, O. Visser, S. Godward, M. P. Coleman, E. M I Williams, D. Forman, M. J. Quinn, M. Roche, S. Edwards, C. Stiller, J. Verne, H. Moller, J. Bell, J. L. Botha, G. Lawrence, R. Black, J. A. Steward

Research output: Contribution to journalArticle

Abstract

BACKGROUND. The survival of patients with Hodgkin disease (HD) varies markedly across Europe and generally is shorter than the survival of patients in the U.S. To investigate these differences, the authors compared population-based HD survival in relation to morphologic type among populations in Europe and the U.S. METHODS. The authors analyzed 6726 patients from 37 cancer registries that participated in EUROCARE-3 and 3442 patients from 9 U.S. Surveillance, Epidemiology, and End Results (SEER) registries. Patients were diagnosed during 1990 to 1994 and were followed for at least 5 years. The European registries were grouped into EUROCARE West, EUROCARE UK, and EUROCARE East. Morphologic groups were nodular sclerosis, mixed cellularity, lymphocyte depletion, lymphocyte predominance, and not otherwise specified (NOS). The influence of morphology on geographic differences in 5-year relative survival was explored by using multiple regression analysis. RESULTS. In the model that was adjusted by age, gender, and years since diagnosis, the relative excess risk (RER) of death was 0.93 (95% confidence interval [95% CI], 0.81-1.05) in EUROCARE West, 1.15 (95% CI, 1.04-1.28) in EUROCARE UK, and 1.39 (95% CI, 1.21-1.60) in EUROCARE East (compared with the SEER data). When morphology was included, EUROCARE UK and SEER no longer differed (RER, 1.06; 95% CI, 0.95-1.18). Morphology distribution varied markedly across Europe and much less in the U.S., with nodular sclerosis less common in Europe (45.9%) than the U.S.(61.7%). The RER data showed that patients who had lymphocyte depletion, NOS, and mixed cellularity had a significantly worse prognoses compared with patients who had nodular sclerosis, whereas patients who had lymphocyte predominance had the best prognosis. CONCLUSIONS. The current results provide population-based evidence that morphology strongly influences the prognosis of patients with HD. However differences in the morphologic case mix explains only some of the geographic variations observed in survival.

Original languageEnglish
Pages (from-to)352-360
Number of pages9
JournalCancer
Volume107
Issue number2
DOIs
Publication statusPublished - Jul 15 2006

Keywords

  • Europe
  • Hodgkin disease
  • Morphology
  • Population cancer registries
  • Relative survival
  • U.S.

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Allemani, C., Sant, M., De Angelis, R., Marcos-Gragera, R., Coebergh, J. W., Oberaigner, W., Storm, H. H., Aareleid, T., Jechova, M., Rousarova, M., Hakulinen, T., Hedelin, G., Tron, I., Le Gall, E., Launoy, G., Mace-Lesec'h, J., Faivre, J., Chaplain, G., Carli, P. M., ... Steward, J. A. (2006). Hodgkin disease survival in Europe and the U.S. Prognostic significance of morphologic groups. Cancer, 107(2), 352-360. https://doi.org/10.1002/cncr.21995