Hodgkin reed–sternberg-like cells in non-hodgkin lymphoma

Research output: Contribution to journalReview articlepeer-review


Reed–Sternberg cells (RSCs) are hallmarks of classic Hodgkin lymphoma (cHL). However, cells with a similar morphology and immunophenotype, so-called Reed–Sternberg-like cells (RSLCs), are occasionally seen in both B cell and T cell non-Hodgkin Lymphomas (NHLs). In NHLs, RSLCs are usually present as scattered elements or in small clusters, and the typical background microenviroment of cHL is usually absent. Nevertheless, in NHLs, the phenotype of RSLCs is very similar to typical RSCs, staining positive for CD30 and EBV, and often for B cell lineage markers, and negative for CD45/LCA. Due to different therapeutic approaches and prognostication, it is mandatory to distinguish between cHL and NHLs. Herein, NHL types in which RSLCs can be detected along with clinicopathological correlation are described. Moreover, the main helpful clues in the differential diagnosis with cHL are summarized.

Original languageEnglish
Article number1019
Issue number12
Publication statusPublished - Dec 2020


  • B cell lymphoma
  • CD30
  • Classic Hodgkin Lymphoma
  • Lymphoma diagnosis
  • Lymphoma diagnostics
  • Reed-Sternberg cell
  • Reed-Sternberg-like cell
  • T cell lymphoma

ASJC Scopus subject areas

  • Clinical Biochemistry


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