TY - JOUR
T1 - Hodgkin's disease
T2 - A disorder of dysregulated cellular cross-talk
AU - Pinto, Antonio
AU - Gattei, Valter
AU - Zagonel, Vittorina
AU - Aldinucci, Donatella
AU - Degan, Massimo
AU - De Iuliis, Angela
AU - Rossi, Francesca Maria
AU - Mazzocco, Francesca Tassan
AU - Godeas, Cristiana
AU - Rupolo, Maurizio
AU - Poletto, Dalisa
AU - Gloghini, Annunziata
AU - Carbone, Antonino
AU - Gruss, Hans Jürgen
PY - 1998
Y1 - 1998
N2 - Hodgkin's disease (HD) is a peculiar type of human malignantly lymphoma characterized by a very low frequency of tumor cells, the so called Hodgkin and Reed-Sternberg (H-RS) cells, embedded in a hyperplastic background of non-neoplastic (reactive) cells recruited and activated by H-RS cells- derived cytokines. H-RS cells can be functionally regarded as antigen- presenting cells (APC) able to elicit an intense, but anergic and ineffective, T-cell mediated immune response along with a hyperplastic inflammatory reaction which involves several cell types including T- and B- cells, neutrophils, eosinophils, plasma cells, fibroblasts and stromal cells. In tissues involved by HD, malignant H-RS cells and their reactive neighboring cells are able to cross-talk via a complex network of cytokine- and cell contact-dependent interactions. As a result of such interactions, mediated by specific surface receptors and adhesion molecules on both tumor and non-neoplastic cells, H-RS cells may receive several proliferative and anti-apoptotic signals favoring the cellular expansion and tumor cell survival in HD. The ineffective T-cell immune response elicited by the abnormal APC function of H-RS cells may further contribute to the biologic and clinical progression of HD. Innovative therapeutic strategies aimed at blocking the pathways of dysregulated cellular cross-talk among H-RS cells and bystander reactive cell populations might be beneficial in the teatment of HD patients.
AB - Hodgkin's disease (HD) is a peculiar type of human malignantly lymphoma characterized by a very low frequency of tumor cells, the so called Hodgkin and Reed-Sternberg (H-RS) cells, embedded in a hyperplastic background of non-neoplastic (reactive) cells recruited and activated by H-RS cells- derived cytokines. H-RS cells can be functionally regarded as antigen- presenting cells (APC) able to elicit an intense, but anergic and ineffective, T-cell mediated immune response along with a hyperplastic inflammatory reaction which involves several cell types including T- and B- cells, neutrophils, eosinophils, plasma cells, fibroblasts and stromal cells. In tissues involved by HD, malignant H-RS cells and their reactive neighboring cells are able to cross-talk via a complex network of cytokine- and cell contact-dependent interactions. As a result of such interactions, mediated by specific surface receptors and adhesion molecules on both tumor and non-neoplastic cells, H-RS cells may receive several proliferative and anti-apoptotic signals favoring the cellular expansion and tumor cell survival in HD. The ineffective T-cell immune response elicited by the abnormal APC function of H-RS cells may further contribute to the biologic and clinical progression of HD. Innovative therapeutic strategies aimed at blocking the pathways of dysregulated cellular cross-talk among H-RS cells and bystander reactive cell populations might be beneficial in the teatment of HD patients.
KW - Cell contact-dependent interactions
KW - Cytokine network
KW - Hodgkin's disease
KW - Human lymphomas
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M3 - Article
C2 - 9592019
AN - SCOPUS:0031897030
VL - 10
SP - 309
EP - 320
JO - Biotherapy
JF - Biotherapy
SN - 0921-299X
IS - 4
ER -