Abstract
Hodgkin's disease (HD) is a peculiar type of human malignantly lymphoma characterized by a very low frequency of tumor cells, the so called Hodgkin and Reed-Sternberg (H-RS) cells, embedded in a hyperplastic background of non-neoplastic (reactive) cells recruited and activated by H-RS cells- derived cytokines. H-RS cells can be functionally regarded as antigen- presenting cells (APC) able to elicit an intense, but anergic and ineffective, T-cell mediated immune response along with a hyperplastic inflammatory reaction which involves several cell types including T- and B- cells, neutrophils, eosinophils, plasma cells, fibroblasts and stromal cells. In tissues involved by HD, malignant H-RS cells and their reactive neighboring cells are able to cross-talk via a complex network of cytokine- and cell contact-dependent interactions. As a result of such interactions, mediated by specific surface receptors and adhesion molecules on both tumor and non-neoplastic cells, H-RS cells may receive several proliferative and anti-apoptotic signals favoring the cellular expansion and tumor cell survival in HD. The ineffective T-cell immune response elicited by the abnormal APC function of H-RS cells may further contribute to the biologic and clinical progression of HD. Innovative therapeutic strategies aimed at blocking the pathways of dysregulated cellular cross-talk among H-RS cells and bystander reactive cell populations might be beneficial in the teatment of HD patients.
| Original language | English |
|---|---|
| Pages (from-to) | 309-320 |
| Number of pages | 12 |
| Journal | Biotherapy |
| Volume | 10 |
| Issue number | 4 |
| Publication status | Published - 1998 |
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Keywords
- Cell contact-dependent interactions
- Cytokine network
- Hodgkin's disease
- Human lymphomas
ASJC Scopus subject areas
- Pharmacology
Cite this
Hodgkin's disease : A disorder of dysregulated cellular cross-talk. / Pinto, Antonio; Gattei, Valter; Zagonel, Vittorina; Aldinucci, Donatella; Degan, Massimo; De Iuliis, Angela; Rossi, Francesca Maria; Mazzocco, Francesca Tassan; Godeas, Cristiana; Rupolo, Maurizio; Poletto, Dalisa; Gloghini, Annunziata; Carbone, Antonino; Gruss, Hans Jürgen.
In: Biotherapy, Vol. 10, No. 4, 1998, p. 309-320.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hodgkin's disease
T2 - A disorder of dysregulated cellular cross-talk
AU - Pinto, Antonio
AU - Gattei, Valter
AU - Zagonel, Vittorina
AU - Aldinucci, Donatella
AU - Degan, Massimo
AU - De Iuliis, Angela
AU - Rossi, Francesca Maria
AU - Mazzocco, Francesca Tassan
AU - Godeas, Cristiana
AU - Rupolo, Maurizio
AU - Poletto, Dalisa
AU - Gloghini, Annunziata
AU - Carbone, Antonino
AU - Gruss, Hans Jürgen
PY - 1998
Y1 - 1998
N2 - Hodgkin's disease (HD) is a peculiar type of human malignantly lymphoma characterized by a very low frequency of tumor cells, the so called Hodgkin and Reed-Sternberg (H-RS) cells, embedded in a hyperplastic background of non-neoplastic (reactive) cells recruited and activated by H-RS cells- derived cytokines. H-RS cells can be functionally regarded as antigen- presenting cells (APC) able to elicit an intense, but anergic and ineffective, T-cell mediated immune response along with a hyperplastic inflammatory reaction which involves several cell types including T- and B- cells, neutrophils, eosinophils, plasma cells, fibroblasts and stromal cells. In tissues involved by HD, malignant H-RS cells and their reactive neighboring cells are able to cross-talk via a complex network of cytokine- and cell contact-dependent interactions. As a result of such interactions, mediated by specific surface receptors and adhesion molecules on both tumor and non-neoplastic cells, H-RS cells may receive several proliferative and anti-apoptotic signals favoring the cellular expansion and tumor cell survival in HD. The ineffective T-cell immune response elicited by the abnormal APC function of H-RS cells may further contribute to the biologic and clinical progression of HD. Innovative therapeutic strategies aimed at blocking the pathways of dysregulated cellular cross-talk among H-RS cells and bystander reactive cell populations might be beneficial in the teatment of HD patients.
AB - Hodgkin's disease (HD) is a peculiar type of human malignantly lymphoma characterized by a very low frequency of tumor cells, the so called Hodgkin and Reed-Sternberg (H-RS) cells, embedded in a hyperplastic background of non-neoplastic (reactive) cells recruited and activated by H-RS cells- derived cytokines. H-RS cells can be functionally regarded as antigen- presenting cells (APC) able to elicit an intense, but anergic and ineffective, T-cell mediated immune response along with a hyperplastic inflammatory reaction which involves several cell types including T- and B- cells, neutrophils, eosinophils, plasma cells, fibroblasts and stromal cells. In tissues involved by HD, malignant H-RS cells and their reactive neighboring cells are able to cross-talk via a complex network of cytokine- and cell contact-dependent interactions. As a result of such interactions, mediated by specific surface receptors and adhesion molecules on both tumor and non-neoplastic cells, H-RS cells may receive several proliferative and anti-apoptotic signals favoring the cellular expansion and tumor cell survival in HD. The ineffective T-cell immune response elicited by the abnormal APC function of H-RS cells may further contribute to the biologic and clinical progression of HD. Innovative therapeutic strategies aimed at blocking the pathways of dysregulated cellular cross-talk among H-RS cells and bystander reactive cell populations might be beneficial in the teatment of HD patients.
KW - Cell contact-dependent interactions
KW - Cytokine network
KW - Hodgkin's disease
KW - Human lymphomas
UR - http://www.scopus.com/inward/record.url?scp=0031897030&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031897030&partnerID=8YFLogxK
M3 - Article
VL - 10
SP - 309
EP - 320
JO - Biotherapy
JF - Biotherapy
SN - 0921-299X
IS - 4
ER -