Hodgkin's disease: A tumor with disturbed immunological pathways

Hans Jürgen Gruss, Antonio Pinto, Justus Duyster, Sibrand Poppema, Friedhelm Herrmann

Research output: Contribution to journalArticle

Abstract

Hodgkin's disease is a lymphoid neoplasia characterized by a low frequency of malignant Hodgkin and Reed-Sternberg (H-RS) cells in an abundant background of non-neoplastic cells. H-RS cells and their neighbors interact via a complex network of cellular activation/adhesion molecules and cytokines. Here, Hans-Jurgen Gruss and colleagues suggest that H-RS cells can be regarded as antigen-presenting cells able to interact with surrounding T cells, resulting in an intense, but ineffective, immune response.

Original languageEnglish
Pages (from-to)156-163
Number of pages8
JournalImmunology Today
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 1997

ASJC Scopus subject areas

  • Immunology

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