Abstract
Here we describe the case of a 14-year-old boy who underwent liver transplantation for post-Kasai biliary atresia when aged 4. Antirejection treatment consisted of prednisone and cyclosporine. At the age of 11 years the patient developed left cervical lymphadenopathy; the biopsy showed classical Hodgkin's disease(HD) of the mixed cellularity (MC) type. Neoplastic cells expressed CD30 and CD15, and were negative for CD45, CD20, CD3, CD43, and CD79a. Furthermore, they carried the EBV-related products LMP1 and EBER1/2. Treatment consisted of three cycles of adriamycin, bleomycin, vinblastine and DTIC (ABVD), followed by radiotherapy (2,000 cGys) on involved fields. At present, 42 months after the diagnosis of HD, the patient is still in complete remission. This is, to the best of our knowledge, the first reported case of classical HD following liver transplantation. The positivity of neoplastic cells for LMP1 and EBER1/2 indicates a possible role for immunosuppression in the development of the tumor, and whether a reduction in immunosuppression might have influenced the course of the disease is open to question.
| Original language | English |
|---|---|
| Pages (from-to) | 673-676 |
| Number of pages | 4 |
| Journal | Annals of Oncology |
| Volume | 9 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1998 |
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Keywords
- Hodgkin's disease
- Immunohistochemistry
- In situ hybridization
- Liver transplantation
- Post-transplant lymphoproliferative disorder
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Hodgkin's disease occurring in a child after liver transplantation. / Conter, V.; Tschümperlin, B.; Gridelli, B.; Lucianetti, A.; Ascani, S.; Bauer, D.; Burnelli, R.; Poggi, S.; Ramaccioni, V.; Milani, M.; Pileri, S. A.
In: Annals of Oncology, Vol. 9, No. 6, 06.1998, p. 673-676.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hodgkin's disease occurring in a child after liver transplantation
AU - Conter, V.
AU - Tschümperlin, B.
AU - Gridelli, B.
AU - Lucianetti, A.
AU - Ascani, S.
AU - Bauer, D.
AU - Burnelli, R.
AU - Poggi, S.
AU - Ramaccioni, V.
AU - Milani, M.
AU - Pileri, S. A.
PY - 1998/6
Y1 - 1998/6
N2 - Here we describe the case of a 14-year-old boy who underwent liver transplantation for post-Kasai biliary atresia when aged 4. Antirejection treatment consisted of prednisone and cyclosporine. At the age of 11 years the patient developed left cervical lymphadenopathy; the biopsy showed classical Hodgkin's disease(HD) of the mixed cellularity (MC) type. Neoplastic cells expressed CD30 and CD15, and were negative for CD45, CD20, CD3, CD43, and CD79a. Furthermore, they carried the EBV-related products LMP1 and EBER1/2. Treatment consisted of three cycles of adriamycin, bleomycin, vinblastine and DTIC (ABVD), followed by radiotherapy (2,000 cGys) on involved fields. At present, 42 months after the diagnosis of HD, the patient is still in complete remission. This is, to the best of our knowledge, the first reported case of classical HD following liver transplantation. The positivity of neoplastic cells for LMP1 and EBER1/2 indicates a possible role for immunosuppression in the development of the tumor, and whether a reduction in immunosuppression might have influenced the course of the disease is open to question.
AB - Here we describe the case of a 14-year-old boy who underwent liver transplantation for post-Kasai biliary atresia when aged 4. Antirejection treatment consisted of prednisone and cyclosporine. At the age of 11 years the patient developed left cervical lymphadenopathy; the biopsy showed classical Hodgkin's disease(HD) of the mixed cellularity (MC) type. Neoplastic cells expressed CD30 and CD15, and were negative for CD45, CD20, CD3, CD43, and CD79a. Furthermore, they carried the EBV-related products LMP1 and EBER1/2. Treatment consisted of three cycles of adriamycin, bleomycin, vinblastine and DTIC (ABVD), followed by radiotherapy (2,000 cGys) on involved fields. At present, 42 months after the diagnosis of HD, the patient is still in complete remission. This is, to the best of our knowledge, the first reported case of classical HD following liver transplantation. The positivity of neoplastic cells for LMP1 and EBER1/2 indicates a possible role for immunosuppression in the development of the tumor, and whether a reduction in immunosuppression might have influenced the course of the disease is open to question.
KW - Hodgkin's disease
KW - Immunohistochemistry
KW - In situ hybridization
KW - Liver transplantation
KW - Post-transplant lymphoproliferative disorder
UR - http://www.scopus.com/inward/record.url?scp=7344264569&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7344264569&partnerID=8YFLogxK
U2 - 10.1023/A:1008220018665
DO - 10.1023/A:1008220018665
M3 - Article
C2 - 9681084
AN - SCOPUS:7344264569
VL - 9
SP - 673
EP - 676
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - 6
ER -