Hodgkin's disease occurring in a child after liver transplantation

V. Conter, B. Tschümperlin, B. Gridelli, A. Lucianetti, S. Ascani, D. Bauer, R. Burnelli, S. Poggi, V. Ramaccioni, M. Milani, S. A. Pileri

Research output: Contribution to journalArticle

Abstract

Here we describe the case of a 14-year-old boy who underwent liver transplantation for post-Kasai biliary atresia when aged 4. Antirejection treatment consisted of prednisone and cyclosporine. At the age of 11 years the patient developed left cervical lymphadenopathy; the biopsy showed classical Hodgkin's disease(HD) of the mixed cellularity (MC) type. Neoplastic cells expressed CD30 and CD15, and were negative for CD45, CD20, CD3, CD43, and CD79a. Furthermore, they carried the EBV-related products LMP1 and EBER1/2. Treatment consisted of three cycles of adriamycin, bleomycin, vinblastine and DTIC (ABVD), followed by radiotherapy (2,000 cGys) on involved fields. At present, 42 months after the diagnosis of HD, the patient is still in complete remission. This is, to the best of our knowledge, the first reported case of classical HD following liver transplantation. The positivity of neoplastic cells for LMP1 and EBER1/2 indicates a possible role for immunosuppression in the development of the tumor, and whether a reduction in immunosuppression might have influenced the course of the disease is open to question.

Original languageEnglish
Pages (from-to)673-676
Number of pages4
JournalAnnals of Oncology
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 1998

Fingerprint

Hodgkin Disease
Liver Transplantation
Immunosuppression
Biliary Atresia
Dacarbazine
Vinblastine
Bleomycin
Prednisone
Human Herpesvirus 4
Doxorubicin
Cyclosporine
Radiotherapy
Biopsy
Therapeutics
Neoplasms
Epstein-Barr virus encoded RNA 1

Keywords

  • Hodgkin's disease
  • Immunohistochemistry
  • In situ hybridization
  • Liver transplantation
  • Post-transplant lymphoproliferative disorder

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Conter, V., Tschümperlin, B., Gridelli, B., Lucianetti, A., Ascani, S., Bauer, D., ... Pileri, S. A. (1998). Hodgkin's disease occurring in a child after liver transplantation. Annals of Oncology, 9(6), 673-676. https://doi.org/10.1023/A:1008220018665

Hodgkin's disease occurring in a child after liver transplantation. / Conter, V.; Tschümperlin, B.; Gridelli, B.; Lucianetti, A.; Ascani, S.; Bauer, D.; Burnelli, R.; Poggi, S.; Ramaccioni, V.; Milani, M.; Pileri, S. A.

In: Annals of Oncology, Vol. 9, No. 6, 06.1998, p. 673-676.

Research output: Contribution to journalArticle

Conter, V, Tschümperlin, B, Gridelli, B, Lucianetti, A, Ascani, S, Bauer, D, Burnelli, R, Poggi, S, Ramaccioni, V, Milani, M & Pileri, SA 1998, 'Hodgkin's disease occurring in a child after liver transplantation', Annals of Oncology, vol. 9, no. 6, pp. 673-676. https://doi.org/10.1023/A:1008220018665
Conter V, Tschümperlin B, Gridelli B, Lucianetti A, Ascani S, Bauer D et al. Hodgkin's disease occurring in a child after liver transplantation. Annals of Oncology. 1998 Jun;9(6):673-676. https://doi.org/10.1023/A:1008220018665
Conter, V. ; Tschümperlin, B. ; Gridelli, B. ; Lucianetti, A. ; Ascani, S. ; Bauer, D. ; Burnelli, R. ; Poggi, S. ; Ramaccioni, V. ; Milani, M. ; Pileri, S. A. / Hodgkin's disease occurring in a child after liver transplantation. In: Annals of Oncology. 1998 ; Vol. 9, No. 6. pp. 673-676.
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