Holoprosencephaly: Prenatal diagnosis by sonography and magnetic resonance imaging

P. Toma, A. Costa, G. M. Magnano, M. Cariati, M. Lituania

Research output: Contribution to journalArticlepeer-review


Magnetic resonance (MR) imaging was performed on two women at the 33rd and 34th pregnancy week, respectively, after ultrasonographic detection of a brain malformation. Fetal neuromuscular blockade was induced by pancuronium bromide injected into the umbilical vein under continuous ultrasound (US) guidance. MR images supported the echotomographic diagnosis of holoprosencephaly, improving the image quality and offering additional information in such cases of difficult differential fetal diagnosis. Holoprosencephaly was finally confirmed by neonatal US and autopsy (case 1), US, CT and MR (case 2).

Original languageEnglish
Pages (from-to)429-436
Number of pages8
JournalPrenatal Diagnosis
Issue number7
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Genetics(clinical)
  • Obstetrics and Gynaecology


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