Abstract
Background. Spinal cord injury causes muscle wasting and loss of function, which are especially severe after complete and permanent damage to lower motor neurons. In a previous cross-sectional study, long-standing denervated muscles were rescued by home-based functional electrical stimulation (h-bFES) training. Objective. To confirm results by a 2-year longitudinal prospective study of 25 patients with complete conus/cauda equina lesions. Methods. Denervated leg muscles were stimulated by h-bFES using a custom-designed stimulator and large surface electrodes. Muscle mass, force, and structure were determined before and after 2 years of h-bFES using computed tomography, measurements of knee torque during stimulation, and muscle biopsies analyzed by histology and electron microscopy. Results. Twenty of 25 patients completed the 2-year h-bFES program, which resulted in (a) a 35% cross-sectional increase in area of the quadriceps muscle from 28.2 ± 8.1 to 38.1 ± 12.7 cm2 (P
| Original language | English |
|---|---|
| Pages (from-to) | 709-721 |
| Number of pages | 13 |
| Journal | Neurorehabilitation and Neural Repair |
| Volume | 24 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Oct 2010 |
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Keywords
- computed tomography
- conus and cauda equina spinal cord injury
- functional electrical stimulation
- human muscle biopsy
- long-term denervation
- lower motor neuron lesion
ASJC Scopus subject areas
- Clinical Neurology
- Rehabilitation
- Neurology
Cite this
Home-based functional electrical stimulation rescues permanently denervated muscles in paraplegic patients with complete lower motor neuron lesion. / Kern, Helmut; Carraro, Ugo; Adami, Nicoletta; Biral, Donatella; Hofer, Christian; Forstner, Claudia; Mödlin, Michaela; Vogelauer, Michael; Pond, Amber; Boncompagni, Simona; Paolini, Cecilia; Mayr, Winfried; Protasi, Feliciano; Zampieri, Sandra.
In: Neurorehabilitation and Neural Repair, Vol. 24, No. 8, 10.2010, p. 709-721.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Home-based functional electrical stimulation rescues permanently denervated muscles in paraplegic patients with complete lower motor neuron lesion
AU - Kern, Helmut
AU - Carraro, Ugo
AU - Adami, Nicoletta
AU - Biral, Donatella
AU - Hofer, Christian
AU - Forstner, Claudia
AU - Mödlin, Michaela
AU - Vogelauer, Michael
AU - Pond, Amber
AU - Boncompagni, Simona
AU - Paolini, Cecilia
AU - Mayr, Winfried
AU - Protasi, Feliciano
AU - Zampieri, Sandra
PY - 2010/10
Y1 - 2010/10
N2 - Background. Spinal cord injury causes muscle wasting and loss of function, which are especially severe after complete and permanent damage to lower motor neurons. In a previous cross-sectional study, long-standing denervated muscles were rescued by home-based functional electrical stimulation (h-bFES) training. Objective. To confirm results by a 2-year longitudinal prospective study of 25 patients with complete conus/cauda equina lesions. Methods. Denervated leg muscles were stimulated by h-bFES using a custom-designed stimulator and large surface electrodes. Muscle mass, force, and structure were determined before and after 2 years of h-bFES using computed tomography, measurements of knee torque during stimulation, and muscle biopsies analyzed by histology and electron microscopy. Results. Twenty of 25 patients completed the 2-year h-bFES program, which resulted in (a) a 35% cross-sectional increase in area of the quadriceps muscle from 28.2 ± 8.1 to 38.1 ± 12.7 cm2 (P
AB - Background. Spinal cord injury causes muscle wasting and loss of function, which are especially severe after complete and permanent damage to lower motor neurons. In a previous cross-sectional study, long-standing denervated muscles were rescued by home-based functional electrical stimulation (h-bFES) training. Objective. To confirm results by a 2-year longitudinal prospective study of 25 patients with complete conus/cauda equina lesions. Methods. Denervated leg muscles were stimulated by h-bFES using a custom-designed stimulator and large surface electrodes. Muscle mass, force, and structure were determined before and after 2 years of h-bFES using computed tomography, measurements of knee torque during stimulation, and muscle biopsies analyzed by histology and electron microscopy. Results. Twenty of 25 patients completed the 2-year h-bFES program, which resulted in (a) a 35% cross-sectional increase in area of the quadriceps muscle from 28.2 ± 8.1 to 38.1 ± 12.7 cm2 (P
KW - computed tomography
KW - conus and cauda equina spinal cord injury
KW - functional electrical stimulation
KW - human muscle biopsy
KW - long-term denervation
KW - lower motor neuron lesion
UR - http://www.scopus.com/inward/record.url?scp=77957746744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957746744&partnerID=8YFLogxK
U2 - 10.1177/1545968310366129
DO - 10.1177/1545968310366129
M3 - Article
C2 - 20460493
AN - SCOPUS:77957746744
VL - 24
SP - 709
EP - 721
JO - Journal of Neurologic Rehabilitation
JF - Journal of Neurologic Rehabilitation
SN - 1545-9683
IS - 8
ER -