TY - JOUR
T1 - Home-based functional electrical stimulation rescues permanently denervated muscles in paraplegic patients with complete lower motor neuron lesion
AU - Kern, Helmut
AU - Carraro, Ugo
AU - Adami, Nicoletta
AU - Biral, Donatella
AU - Hofer, Christian
AU - Forstner, Claudia
AU - Mödlin, Michaela
AU - Vogelauer, Michael
AU - Pond, Amber
AU - Boncompagni, Simona
AU - Paolini, Cecilia
AU - Mayr, Winfried
AU - Protasi, Feliciano
AU - Zampieri, Sandra
PY - 2010/10
Y1 - 2010/10
N2 - Background. Spinal cord injury causes muscle wasting and loss of function, which are especially severe after complete and permanent damage to lower motor neurons. In a previous cross-sectional study, long-standing denervated muscles were rescued by home-based functional electrical stimulation (h-bFES) training. Objective. To confirm results by a 2-year longitudinal prospective study of 25 patients with complete conus/cauda equina lesions. Methods. Denervated leg muscles were stimulated by h-bFES using a custom-designed stimulator and large surface electrodes. Muscle mass, force, and structure were determined before and after 2 years of h-bFES using computed tomography, measurements of knee torque during stimulation, and muscle biopsies analyzed by histology and electron microscopy. Results. Twenty of 25 patients completed the 2-year h-bFES program, which resulted in (a) a 35% cross-sectional increase in area of the quadriceps muscle from 28.2 ± 8.1 to 38.1 ± 12.7 cm2 (P
AB - Background. Spinal cord injury causes muscle wasting and loss of function, which are especially severe after complete and permanent damage to lower motor neurons. In a previous cross-sectional study, long-standing denervated muscles were rescued by home-based functional electrical stimulation (h-bFES) training. Objective. To confirm results by a 2-year longitudinal prospective study of 25 patients with complete conus/cauda equina lesions. Methods. Denervated leg muscles were stimulated by h-bFES using a custom-designed stimulator and large surface electrodes. Muscle mass, force, and structure were determined before and after 2 years of h-bFES using computed tomography, measurements of knee torque during stimulation, and muscle biopsies analyzed by histology and electron microscopy. Results. Twenty of 25 patients completed the 2-year h-bFES program, which resulted in (a) a 35% cross-sectional increase in area of the quadriceps muscle from 28.2 ± 8.1 to 38.1 ± 12.7 cm2 (P
KW - computed tomography
KW - conus and cauda equina spinal cord injury
KW - functional electrical stimulation
KW - human muscle biopsy
KW - long-term denervation
KW - lower motor neuron lesion
UR - http://www.scopus.com/inward/record.url?scp=77957746744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77957746744&partnerID=8YFLogxK
U2 - 10.1177/1545968310366129
DO - 10.1177/1545968310366129
M3 - Article
C2 - 20460493
AN - SCOPUS:77957746744
VL - 24
SP - 709
EP - 721
JO - Journal of Neurologic Rehabilitation
JF - Journal of Neurologic Rehabilitation
SN - 1545-9683
IS - 8
ER -