TY - JOUR
T1 - Homeobox genes and cancer
AU - Cillo, Clemente
AU - Faiella, Antonio
AU - Cantile, Monica
AU - Boncinelli, Edoardo
PY - 1999/4/10
Y1 - 1999/4/10
N2 - Homeobox-containing genes are a family of regulatory genes encoding transcription factors that primarily play a crucial role during development. Several indications suggest their involvement in the control of cell growth and, when dysregulated, in oncogenesis. We will describe the implications, in tumor origin and evolution, of members of the homeobox gene families HOX, EMX, PAX, and MSX as well as of other divergent homeobox genes. We will also propose a model for the function of the HOX gene network in controlling cell identity to account for the involvement of some HOX genes in both normal development and oncogenesis.
AB - Homeobox-containing genes are a family of regulatory genes encoding transcription factors that primarily play a crucial role during development. Several indications suggest their involvement in the control of cell growth and, when dysregulated, in oncogenesis. We will describe the implications, in tumor origin and evolution, of members of the homeobox gene families HOX, EMX, PAX, and MSX as well as of other divergent homeobox genes. We will also propose a model for the function of the HOX gene network in controlling cell identity to account for the involvement of some HOX genes in both normal development and oncogenesis.
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U2 - 10.1006/excr.1999.4451
DO - 10.1006/excr.1999.4451
M3 - Article
C2 - 10094807
AN - SCOPUS:0033541435
VL - 248
SP - 1
EP - 9
JO - Experimental Cell Research
JF - Experimental Cell Research
SN - 0014-4827
IS - 1
ER -