Homeobox genes and cancer

Clemente Cillo, Antonio Faiella, Monica Cantile, Edoardo Boncinelli

Research output: Contribution to journalArticlepeer-review

Abstract

Homeobox-containing genes are a family of regulatory genes encoding transcription factors that primarily play a crucial role during development. Several indications suggest their involvement in the control of cell growth and, when dysregulated, in oncogenesis. We will describe the implications, in tumor origin and evolution, of members of the homeobox gene families HOX, EMX, PAX, and MSX as well as of other divergent homeobox genes. We will also propose a model for the function of the HOX gene network in controlling cell identity to account for the involvement of some HOX genes in both normal development and oncogenesis.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalExperimental Cell Research
Volume248
Issue number1
DOIs
Publication statusPublished - Apr 10 1999

ASJC Scopus subject areas

  • Cell Biology

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