Homeostatic T cell proliferation after islet transplantation

Paolo Monti, Lorenzo Piemonti

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Pancreatic islet transplantation in patients with type 1 diabetes mellitus is performed under immunosuppression to avoid alloreactive T cell responses and to control the reactivation of autoreactive memory T cells. However, lymphopenia associated with immunosuppression and T cell depletion can induce a paradoxical expansion of lymphocyte subsets under the influence of homeostatic proliferation. Homeostatic T cell proliferation is mainly driven by the IL-7/IL-7 receptor axis, a molecular pathway which is not affected by standard immune-suppressive drugs and, consequently, represents a novel potential target for immuno-modulatory strategies. In this review, we will discuss how homeostatic T cell proliferation can support autoimmunity recurrence after islet transplantation and how it can be targeted by new therapeutic approaches.

Original languageEnglish
Article number217934
JournalClinical and Developmental Immunology
Volume2013
DOIs
Publication statusPublished - 2013

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Islets of Langerhans Transplantation
Cell Proliferation
T-Lymphocytes
Immunosuppression
Interleukin-7 Receptors
Interleukin-7
Lymphopenia
Lymphocyte Subsets
Autoimmunity
Type 1 Diabetes Mellitus
Recurrence
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Homeostatic T cell proliferation after islet transplantation. / Monti, Paolo; Piemonti, Lorenzo.

In: Clinical and Developmental Immunology, Vol. 2013, 217934, 2013.

Research output: Contribution to journalArticle

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