Homocysteine and electroencephalographic rhythms in Alzheimer disease: A multicentric study

C. Babiloni, P. Bosco, R. Ghidoni, C. Del Percio, R. Squitti, G. Binetti, L. Benussi, R. Ferri, G. Frisoni, B. Lanuzza, E. Cassetta, G. Anello, M. Gurzì, S. Bartesaghi, R. Lizio, M. Tombini, P. M. Rossini

Research output: Contribution to journalArticlepeer-review

Abstract

High plasma concentration of homocysteine is an independent risk factor for Alzheimer's disease (AD), due to microvascular impairment and consequent neural loss [Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA (2002) Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346(7):476-483]. Is high plasma homocysteine level related to slow electroencephalographic (EEG) rhythms in awake resting AD subjects, as a reflection of known relationships between cortical neural loss and these rhythms? To test this hypothesis, we enrolled 34 mild AD patients and 34 subjects with mild cognitive impairment (MCI). Enrolled people were then subdivided into four sub-groups of 17 persons: MCI and AD subjects with low homocysteine level (MCI- and AD-, homocysteine level

Original languageEnglish
Pages (from-to)942-954
Number of pages13
JournalNeuroscience
Volume145
Issue number3
DOIs
Publication statusPublished - Mar 30 2007

Keywords

  • Alzheimer's disease
  • electroencephalography
  • homocysteine
  • low resolution brain electromagnetic tomography
  • mild cognitive impairment

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Homocysteine and electroencephalographic rhythms in Alzheimer disease: A multicentric study'. Together they form a unique fingerprint.

Cite this