Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease

Guido Anello; Rosa Maria Guéant-Rodríguez; Paolo Bosco; Jean Louis Guéant; Antonino Romano; Bernard Namour; Rosario Spada; Filippo Caraci; Gregory Pourié; Jean L. Daval; Raffaele Ferri

doi:10.1097/00001756-200404090-00025

Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease

Guido Anello, Rosa Maria Guéant-Rodríguez, Paolo Bosco, Jean Louis Guéant, Antonino Romano, Bernard Namour, Rosario Spada, Filippo Caraci, Gregory Pourié, Jean L. Daval, Raffaele Ferri

www.irccs.oasi.en.it

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Abstract

Homocysteine metabolism is influenced by genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR 677 C → T and 1298 A → C) and transcobalamin genes (TCNI 776 C → G ). We evaluated the association of homocysteine with Alzheimer's disease (AD) and the influence of related polymorphisms and APOE, in 180 cases and 181 controls from southern Italy. Homocysteine (upper tercile) was associated with AD risk, with an odds ratio of 2.8 (95% confidence interval (CI) 1.54-5.22, p=0.0008), which was increased 2.2- and 2.0-fold by MTHFR 677 T (odds ratio 6.28, 95% CI 2.88-16.20, p <0.0001) and APOE ε4 (odds ratio: 5.60, 95% CI 1.12-28.05, p=0.0361), respectively. In conclusion, association of homocysteine with AD was aggravated by MTHFR 677 T and APOE ε4 alleles.

Original language	English
Pages (from-to)	859-861
Number of pages	3
Journal	NeuroReport
Volume	15
Issue number	5
DOIs	https://doi.org/10.1097/00001756-200404090-00025
Publication status	Published - Apr 9 2004

Keywords

Alzheimer's disease
Homocysteine
Methylene tetrahydrofolate reductase
Transcobalamin

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-200404090-00025

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title = "Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease",

abstract = "Homocysteine metabolism is influenced by genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR 677 C → T and 1298 A → C) and transcobalamin genes (TCNI 776 C → G ). We evaluated the association of homocysteine with Alzheimer's disease (AD) and the influence of related polymorphisms and APOE, in 180 cases and 181 controls from southern Italy. Homocysteine (upper tercile) was associated with AD risk, with an odds ratio of 2.8 (95% confidence interval (CI) 1.54-5.22, p=0.0008), which was increased 2.2- and 2.0-fold by MTHFR 677 T (odds ratio 6.28, 95% CI 2.88-16.20, p <0.0001) and APOE ε4 (odds ratio: 5.60, 95% CI 1.12-28.05, p=0.0361), respectively. In conclusion, association of homocysteine with AD was aggravated by MTHFR 677 T and APOE ε4 alleles.",

keywords = "Alzheimer's disease, Homocysteine, Methylene tetrahydrofolate reductase, Transcobalamin",

author = "Guido Anello and Gu{\'e}ant-Rodr{\'i}guez, {Rosa Maria} and Paolo Bosco and Gu{\'e}ant, {Jean Louis} and Antonino Romano and Bernard Namour and Rosario Spada and Filippo Caraci and Gregory Pouri{\'e} and Daval, {Jean L.} and Raffaele Ferri",

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doi = "10.1097/00001756-200404090-00025",

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AU - Anello, Guido

AU - Guéant-Rodríguez, Rosa Maria

AU - Bosco, Paolo

AU - Guéant, Jean Louis

AU - Romano, Antonino

AU - Namour, Bernard

AU - Spada, Rosario

AU - Caraci, Filippo

AU - Pourié, Gregory

AU - Daval, Jean L.

AU - Ferri, Raffaele

PY - 2004/4/9

Y1 - 2004/4/9

N2 - Homocysteine metabolism is influenced by genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR 677 C → T and 1298 A → C) and transcobalamin genes (TCNI 776 C → G ). We evaluated the association of homocysteine with Alzheimer's disease (AD) and the influence of related polymorphisms and APOE, in 180 cases and 181 controls from southern Italy. Homocysteine (upper tercile) was associated with AD risk, with an odds ratio of 2.8 (95% confidence interval (CI) 1.54-5.22, p=0.0008), which was increased 2.2- and 2.0-fold by MTHFR 677 T (odds ratio 6.28, 95% CI 2.88-16.20, p <0.0001) and APOE ε4 (odds ratio: 5.60, 95% CI 1.12-28.05, p=0.0361), respectively. In conclusion, association of homocysteine with AD was aggravated by MTHFR 677 T and APOE ε4 alleles.

AB - Homocysteine metabolism is influenced by genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR 677 C → T and 1298 A → C) and transcobalamin genes (TCNI 776 C → G ). We evaluated the association of homocysteine with Alzheimer's disease (AD) and the influence of related polymorphisms and APOE, in 180 cases and 181 controls from southern Italy. Homocysteine (upper tercile) was associated with AD risk, with an odds ratio of 2.8 (95% confidence interval (CI) 1.54-5.22, p=0.0008), which was increased 2.2- and 2.0-fold by MTHFR 677 T (odds ratio 6.28, 95% CI 2.88-16.20, p <0.0001) and APOE ε4 (odds ratio: 5.60, 95% CI 1.12-28.05, p=0.0361), respectively. In conclusion, association of homocysteine with AD was aggravated by MTHFR 677 T and APOE ε4 alleles.

KW - Alzheimer's disease

KW - Homocysteine

KW - Methylene tetrahydrofolate reductase

KW - Transcobalamin

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Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease

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