TY - JOUR
T1 - Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease
AU - Anello, Guido
AU - Guéant-Rodríguez, Rosa Maria
AU - Bosco, Paolo
AU - Guéant, Jean Louis
AU - Romano, Antonino
AU - Namour, Bernard
AU - Spada, Rosario
AU - Caraci, Filippo
AU - Pourié, Gregory
AU - Daval, Jean L.
AU - Ferri, Raffaele
PY - 2004/4/9
Y1 - 2004/4/9
N2 - Homocysteine metabolism is influenced by genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR 677 C → T and 1298 A → C) and transcobalamin genes (TCNI 776 C → G ). We evaluated the association of homocysteine with Alzheimer's disease (AD) and the influence of related polymorphisms and APOE, in 180 cases and 181 controls from southern Italy. Homocysteine (upper tercile) was associated with AD risk, with an odds ratio of 2.8 (95% confidence interval (CI) 1.54-5.22, p=0.0008), which was increased 2.2- and 2.0-fold by MTHFR 677 T (odds ratio 6.28, 95% CI 2.88-16.20, p <0.0001) and APOE ε4 (odds ratio: 5.60, 95% CI 1.12-28.05, p=0.0361), respectively. In conclusion, association of homocysteine with AD was aggravated by MTHFR 677 T and APOE ε4 alleles.
AB - Homocysteine metabolism is influenced by genetic polymorphisms of the methylenetetrahydrofolate reductase (MTHFR 677 C → T and 1298 A → C) and transcobalamin genes (TCNI 776 C → G ). We evaluated the association of homocysteine with Alzheimer's disease (AD) and the influence of related polymorphisms and APOE, in 180 cases and 181 controls from southern Italy. Homocysteine (upper tercile) was associated with AD risk, with an odds ratio of 2.8 (95% confidence interval (CI) 1.54-5.22, p=0.0008), which was increased 2.2- and 2.0-fold by MTHFR 677 T (odds ratio 6.28, 95% CI 2.88-16.20, p <0.0001) and APOE ε4 (odds ratio: 5.60, 95% CI 1.12-28.05, p=0.0361), respectively. In conclusion, association of homocysteine with AD was aggravated by MTHFR 677 T and APOE ε4 alleles.
KW - Alzheimer's disease
KW - Homocysteine
KW - Methylene tetrahydrofolate reductase
KW - Transcobalamin
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U2 - 10.1097/00001756-200404090-00025
DO - 10.1097/00001756-200404090-00025
M3 - Article
C2 - 15073531
AN - SCOPUS:11144354439
VL - 15
SP - 859
EP - 861
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 5
ER -