Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an Ambulatory Elderly Population

Rosa Maria Guéant-Rodriguez, Rosario Spada, Maira Moreno-Garcia, Guido Anello, Paolo Bosco, Laurent Lagrost, Antonino Romano, Maurizio Elia, Jean Louis Guéant

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: The ankle brachial index (ABI) is an indicator of lower extremity peripheral arterial disease (PAD) and a predictor of atherothrombosis. ApoA-I and HDL are associated with PAD, in humans. Homocysteine influences the liver expression of ApoA-I and decreases its blood level and HDL in genetic mice models. We aimed therefore to evaluate whether homocysteine and its nutritional determinants, folate and vitamin B12 are associated with ABI by influencing HDL metabolism, in an ambulatory elderly population. Methods: 667 elderly volunteers from rural Sicily were assessed for ABI, homocysteine and its determinants, lipid markers and other predictors of PAD. HDL size was assessed in 15 sera in upper and lower quartiles of Hcy distribution. Results: In multivariate analysis, ApoA-I and homocysteine were two predictors of ABI (β-coefficient = 2.86, p<0.004 and β-coefficient = -3.41, p<0.001, respectively). Homocysteine correlated negatively with ApoA-I (R = -0.147, p<0.001) and with HDL-Cholesterol (R = -0.113, P = 0.003). The associations of homocysteine, vitamin B12 and methylmalonic acid with ApoA-I and HDL2a particles and that of homocysteine with increased small size HDL3c suggested mechanisms related with impaired synthesis of ApoA-I and HDL and abnormal maturation of HDL particles. Conclusion: The influence of homocysteine on ApoA-I and HDL metabolism provides new insights on its role on vascular diseases, at a cross-point between atherosclerosis and atherothrombosis.

Original languageEnglish
Pages (from-to)480-485
Number of pages6
JournalAtherosclerosis
Volume214
Issue number2
DOIs
Publication statusPublished - Feb 2011

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Ankle Brachial Index
Apolipoprotein A-I
Homocysteine
Population
Peripheral Arterial Disease
Vitamin B 12
Methylmalonic Acid
Sicily
Genetic Models
Vascular Diseases
Folic Acid
HDL Cholesterol
Volunteers
Lower Extremity
Atherosclerosis
Multivariate Analysis
Lipids
Liver

Keywords

  • Ankle brachial index
  • Folate
  • HDL
  • Homocysteine
  • Vitamin B12

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an Ambulatory Elderly Population. / Guéant-Rodriguez, Rosa Maria; Spada, Rosario; Moreno-Garcia, Maira; Anello, Guido; Bosco, Paolo; Lagrost, Laurent; Romano, Antonino; Elia, Maurizio; Guéant, Jean Louis.

In: Atherosclerosis, Vol. 214, No. 2, 02.2011, p. 480-485.

Research output: Contribution to journalArticle

Guéant-Rodriguez, Rosa Maria ; Spada, Rosario ; Moreno-Garcia, Maira ; Anello, Guido ; Bosco, Paolo ; Lagrost, Laurent ; Romano, Antonino ; Elia, Maurizio ; Guéant, Jean Louis. / Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an Ambulatory Elderly Population. In: Atherosclerosis. 2011 ; Vol. 214, No. 2. pp. 480-485.
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T1 - Homocysteine is a determinant of ApoA-I and both are associated with ankle brachial index, in an Ambulatory Elderly Population

AU - Guéant-Rodriguez, Rosa Maria

AU - Spada, Rosario

AU - Moreno-Garcia, Maira

AU - Anello, Guido

AU - Bosco, Paolo

AU - Lagrost, Laurent

AU - Romano, Antonino

AU - Elia, Maurizio

AU - Guéant, Jean Louis

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N2 - Objective: The ankle brachial index (ABI) is an indicator of lower extremity peripheral arterial disease (PAD) and a predictor of atherothrombosis. ApoA-I and HDL are associated with PAD, in humans. Homocysteine influences the liver expression of ApoA-I and decreases its blood level and HDL in genetic mice models. We aimed therefore to evaluate whether homocysteine and its nutritional determinants, folate and vitamin B12 are associated with ABI by influencing HDL metabolism, in an ambulatory elderly population. Methods: 667 elderly volunteers from rural Sicily were assessed for ABI, homocysteine and its determinants, lipid markers and other predictors of PAD. HDL size was assessed in 15 sera in upper and lower quartiles of Hcy distribution. Results: In multivariate analysis, ApoA-I and homocysteine were two predictors of ABI (β-coefficient = 2.86, p<0.004 and β-coefficient = -3.41, p<0.001, respectively). Homocysteine correlated negatively with ApoA-I (R = -0.147, p<0.001) and with HDL-Cholesterol (R = -0.113, P = 0.003). The associations of homocysteine, vitamin B12 and methylmalonic acid with ApoA-I and HDL2a particles and that of homocysteine with increased small size HDL3c suggested mechanisms related with impaired synthesis of ApoA-I and HDL and abnormal maturation of HDL particles. Conclusion: The influence of homocysteine on ApoA-I and HDL metabolism provides new insights on its role on vascular diseases, at a cross-point between atherosclerosis and atherothrombosis.

AB - Objective: The ankle brachial index (ABI) is an indicator of lower extremity peripheral arterial disease (PAD) and a predictor of atherothrombosis. ApoA-I and HDL are associated with PAD, in humans. Homocysteine influences the liver expression of ApoA-I and decreases its blood level and HDL in genetic mice models. We aimed therefore to evaluate whether homocysteine and its nutritional determinants, folate and vitamin B12 are associated with ABI by influencing HDL metabolism, in an ambulatory elderly population. Methods: 667 elderly volunteers from rural Sicily were assessed for ABI, homocysteine and its determinants, lipid markers and other predictors of PAD. HDL size was assessed in 15 sera in upper and lower quartiles of Hcy distribution. Results: In multivariate analysis, ApoA-I and homocysteine were two predictors of ABI (β-coefficient = 2.86, p<0.004 and β-coefficient = -3.41, p<0.001, respectively). Homocysteine correlated negatively with ApoA-I (R = -0.147, p<0.001) and with HDL-Cholesterol (R = -0.113, P = 0.003). The associations of homocysteine, vitamin B12 and methylmalonic acid with ApoA-I and HDL2a particles and that of homocysteine with increased small size HDL3c suggested mechanisms related with impaired synthesis of ApoA-I and HDL and abnormal maturation of HDL particles. Conclusion: The influence of homocysteine on ApoA-I and HDL metabolism provides new insights on its role on vascular diseases, at a cross-point between atherosclerosis and atherothrombosis.

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KW - Folate

KW - HDL

KW - Homocysteine

KW - Vitamin B12

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