Abstract
Hyperhomocysteinemia could play a similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy.We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 ± 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7%) foetuses were males, 201 (46.3%) females.The mean homocysteine concentration was 1.04 ± 0.72 μM, (95% C.I. 0.43-2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p
| Original language | English |
|---|---|
| Pages (from-to) | 625-628 |
| Number of pages | 4 |
| Journal | Thrombosis and Haemostasis |
| Volume | 95 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2006 |
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Keywords
- Amniotic fluid
- Foetal growth
- Homocysteine
- Prenatal diagnosis
ASJC Scopus subject areas
- Hematology
Cite this
Homocysteine levels in amniotic fluid. Relationship with birth-weight. / Grandone, Elvira; Colaizzo, Donatella; Vecchione, Gennaro; Sciannamè, Natale; Notarangelo, Angelo; Croce, Anna Irma; Margaglione, Maurizio.
In: Thrombosis and Haemostasis, Vol. 95, No. 4, 04.2006, p. 625-628.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Homocysteine levels in amniotic fluid. Relationship with birth-weight
AU - Grandone, Elvira
AU - Colaizzo, Donatella
AU - Vecchione, Gennaro
AU - Sciannamè, Natale
AU - Notarangelo, Angelo
AU - Croce, Anna Irma
AU - Margaglione, Maurizio
PY - 2006/4
Y1 - 2006/4
N2 - Hyperhomocysteinemia could play a similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy.We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 ± 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7%) foetuses were males, 201 (46.3%) females.The mean homocysteine concentration was 1.04 ± 0.72 μM, (95% C.I. 0.43-2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p
AB - Hyperhomocysteinemia could play a similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy.We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 ± 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7%) foetuses were males, 201 (46.3%) females.The mean homocysteine concentration was 1.04 ± 0.72 μM, (95% C.I. 0.43-2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p
KW - Amniotic fluid
KW - Foetal growth
KW - Homocysteine
KW - Prenatal diagnosis
UR - http://www.scopus.com/inward/record.url?scp=33645740196&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33645740196&partnerID=8YFLogxK
U2 - 10.1160/TH05-06-0427
DO - 10.1160/TH05-06-0427
M3 - Article
C2 - 16601832
AN - SCOPUS:33645740196
VL - 95
SP - 625
EP - 628
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 4
ER -