Homocysteine levels in amniotic fluid. Relationship with birth-weight

Elvira Grandone, Donatella Colaizzo, Gennaro Vecchione, Natale Sciannamè, Angelo Notarangelo, Anna Irma Croce, Maurizio Margaglione

Research output: Contribution to journalArticlepeer-review


Hyperhomocysteinemia could play a similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy.We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 ± 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7%) foetuses were males, 201 (46.3%) females.The mean homocysteine concentration was 1.04 ± 0.72 μM, (95% C.I. 0.43-2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p

Original languageEnglish
Pages (from-to)625-628
Number of pages4
JournalThrombosis and Haemostasis
Issue number4
Publication statusPublished - Apr 2006


  • Amniotic fluid
  • Foetal growth
  • Homocysteine
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Hematology


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