Homocysteine levels in amniotic fluid. Relationship with birth-weight

Elvira Grandone, Donatella Colaizzo, Gennaro Vecchione, Natale Sciannamè, Angelo Notarangelo, Anna Irma Croce, Maurizio Margaglione

Research output: Contribution to journalArticle

Abstract

Hyperhomocysteinemia could play a similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy.We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 ± 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7%) foetuses were males, 201 (46.3%) females.The mean homocysteine concentration was 1.04 ± 0.72 μM, (95% C.I. 0.43-2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p

Original languageEnglish
Pages (from-to)625-628
Number of pages4
JournalThrombosis and Haemostasis
Volume95
Issue number4
DOIs
Publication statusPublished - Apr 2006

Fingerprint

Homocysteine
Amniotic Fluid
Birth Weight
Femur
Gestational Age
Hyperhomocysteinemia
Pregnancy
Twin Pregnancy
Amniocentesis
Maternal Age
Second Pregnancy Trimester
Pregnancy Outcome
Placenta
Linear Models
Fetus
Thrombosis
Biomarkers
Parturition
Newborn Infant

Keywords

  • Amniotic fluid
  • Foetal growth
  • Homocysteine
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Hematology

Cite this

Homocysteine levels in amniotic fluid. Relationship with birth-weight. / Grandone, Elvira; Colaizzo, Donatella; Vecchione, Gennaro; Sciannamè, Natale; Notarangelo, Angelo; Croce, Anna Irma; Margaglione, Maurizio.

In: Thrombosis and Haemostasis, Vol. 95, No. 4, 04.2006, p. 625-628.

Research output: Contribution to journalArticle

Grandone, Elvira ; Colaizzo, Donatella ; Vecchione, Gennaro ; Sciannamè, Natale ; Notarangelo, Angelo ; Croce, Anna Irma ; Margaglione, Maurizio. / Homocysteine levels in amniotic fluid. Relationship with birth-weight. In: Thrombosis and Haemostasis. 2006 ; Vol. 95, No. 4. pp. 625-628.
@article{ee8a6952407441419209b0406eea17c3,
title = "Homocysteine levels in amniotic fluid. Relationship with birth-weight",
abstract = "Hyperhomocysteinemia could play a similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy.We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 ± 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7{\%}) foetuses were males, 201 (46.3{\%}) females.The mean homocysteine concentration was 1.04 ± 0.72 μM, (95{\%} C.I. 0.43-2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p",
keywords = "Amniotic fluid, Foetal growth, Homocysteine, Prenatal diagnosis",
author = "Elvira Grandone and Donatella Colaizzo and Gennaro Vecchione and Natale Sciannam{\`e} and Angelo Notarangelo and Croce, {Anna Irma} and Maurizio Margaglione",
year = "2006",
month = "4",
doi = "10.1160/TH05-06-0427",
language = "English",
volume = "95",
pages = "625--628",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer GmbH",
number = "4",

}

TY - JOUR

T1 - Homocysteine levels in amniotic fluid. Relationship with birth-weight

AU - Grandone, Elvira

AU - Colaizzo, Donatella

AU - Vecchione, Gennaro

AU - Sciannamè, Natale

AU - Notarangelo, Angelo

AU - Croce, Anna Irma

AU - Margaglione, Maurizio

PY - 2006/4

Y1 - 2006/4

N2 - Hyperhomocysteinemia could play a similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy.We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 ± 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7%) foetuses were males, 201 (46.3%) females.The mean homocysteine concentration was 1.04 ± 0.72 μM, (95% C.I. 0.43-2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p

AB - Hyperhomocysteinemia could play a similar role in the placenta to that played in adults at risk of thrombosis. Moreover, hyperhomocysteinemia in women is described to be associated with the birth of small for gestational age (SGA) newborns, although there are discrepancies on this issue. To date, there is no biochemical marker predictive of SGA in a given pregnancy.We verified the presence of a relationship between homocysteine in amniotic fluid at mid-pregnancy and birth-weight. Amniotic fluid was obtained from 459 healthy women undergoing midtrimester amniocentesis (17.1 ± 1.2 weeks) because of maternal age. Homocysteine levels were measured in 434 (10 twin) pregnancies. In addition, femur length (FL) and biparietal diameter (BPD) were measured. Outcome of pregnancy was recorded. 233 (53.7%) foetuses were males, 201 (46.3%) females.The mean homocysteine concentration was 1.04 ± 0.72 μM, (95% C.I. 0.43-2.41). An univariate analysis showed the presence of an association with gestational age, FL, BPD. A multiple linear regression showed that homocysteine levels were significantly associated with FL (p

KW - Amniotic fluid

KW - Foetal growth

KW - Homocysteine

KW - Prenatal diagnosis

UR - http://www.scopus.com/inward/record.url?scp=33645740196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645740196&partnerID=8YFLogxK

U2 - 10.1160/TH05-06-0427

DO - 10.1160/TH05-06-0427

M3 - Article

C2 - 16601832

AN - SCOPUS:33645740196

VL - 95

SP - 625

EP - 628

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 4

ER -